Extramitochondrial cardiolipin suggests a novel function of mitochondria in spermatogenesis

Mitochondria contain cardiolipin (CL), an organelle-specific phospholipid that carries four fatty acids with a strong preference for unsaturated chains. Unsaturation is essential for the stability and for the function of mitochondrial CL. Surprisingly, we found tetrapalmitoyl-CL (TPCL), a fully satu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of cell biology 2019-05, Vol.218 (5), p.1491-1502
Hauptverfasser:	Ren, Mindong, Xu, Yang, Erdjument-Bromage, Hediye, Donelian, Alec, Phoon, Colin K L, Terada, Naohiro, Strathdee, Douglas, Neubert, Thomas A, Schlame, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome - metabolism Animals Cardiolipin Cardiolipins - metabolism Cell membranes Fatty acids Germ cells Golgi apparatus Golgi Apparatus - metabolism Humans Lipids - analysis Male Membranes Mice Mice, Inbred C57BL Mitochondria Mitochondria - physiology Mitochondrial Membranes - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Phospholipids Proteome - analysis Spermatogenesis Spermiogenesis Substrates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!