Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct anatomical sites are poorly understood. Using intravital imaging, we tracked interactions established by anti-CD19 CAR T cells in B cell lymphoma-be...

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Veröffentlicht in:	The Journal of experimental medicine 2019-05, Vol.216 (5), p.1038-1049
Hauptverfasser:	Cazaux, Marine, Grandjean, Capucine L, Lemaître, Fabrice, Garcia, Zacarias, Beck, Richard J, Milo, Idan, Postat, Jérémy, Beltman, Joost B, Cheadle, Eleanor J, Bousso, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD19 - metabolism Apoptosis Cancer Cell Line, Tumor Immunology Immunotherapy Immunotherapy, Adoptive - methods Intravital Microscopy - methods Life Sciences Lung - metabolism Lymphoma, B-Cell - pathology Lymphoma, B-Cell - therapy Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Models, Theoretical Receptors, Chimeric Antigen - metabolism Recurrence Single-Cell Analysis - methods T-Lymphocytes - metabolism
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