Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression

The associated increase in the lipopolysaccharide (LPS) levels and uremic toxins in chronic kidney disease (CKD) has shifted the way we focus on intestinal microbiota. This study shows that a disruption of the intestinal barrier in CKD promotes leakage of LPS from the gut, subsequently decreasing in...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2019-05, Vol.34 (5), p.783-794
Hauptverfasser:	Gonzalez, Austin, Krieg, Richard, Massey, Hugh D, Carl, Daniel, Ghosh, Shobha, Gehr, Todd W B, Ghosh, Siddhartha S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Butyric Acid - pharmacology Disease Models, Animal Histamine Antagonists - pharmacology Immunohistochemistry Insulin Resistance - physiology Intestinal Mucosa - metabolism Male Mucins - biosynthesis ORIGINAL ARTICLES Permeability Rats Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - metabolism
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