A complex containing lysine-acetylated actin inhibits the formin INF2

Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. Dominant missense mutations in INF2 are linked to two diseases: focal segmental glomerulosclerosis, a kidney disease, and Charcot–Marie–Tooth disease, a neuropathy. All of the disease mutations map to the autoinhibi...

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Veröffentlicht in:	Nature cell biology 2019-05, Vol.21 (5), p.592-602
Hauptverfasser:	A, Mu, Fung, Tak Shun, Kettenbach, Arminja N., Chakrabarti, Rajarshi, Higgs, Henry N.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/19 14/35 14/63 631/80/128/1276 631/80/458/1275 9/10 Actin Actins - chemistry Actins - genetics Amino acids Animal tissues Animals Assembly Biomedical and Life Sciences Brain Brain - metabolism Brain - pathology Cancer Research Carrier Proteins - chemistry Carrier Proteins - genetics Cell Biology Charcot-Marie-Tooth disease Charcot-Marie-Tooth Disease - genetics Charcot-Marie-Tooth Disease - pathology Developmental Biology Disease Formins Glomerulosclerosis, Focal Segmental - genetics Glomerulosclerosis, Focal Segmental - pathology Histone deacetylase Histone Deacetylase 6 - antagonists & inhibitors Histone Deacetylase 6 - genetics Humans Inhibitors Kidney diseases Life Sciences Lysine Lysine - chemistry Mice Microfilament Proteins - chemistry Microfilament Proteins - genetics Missense mutation Muscle proteins Mutation Neuropathy Protein Binding Protein Domains - genetics Protein research Stem Cells
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