Piperine Enhances the Antioxidant and Anti-Inflammatory Activities of Thymoquinone against Microcystin-LR-Induced Hepatotoxicity and Neurotoxicity in Mice

Microcystin- (MC-) LR is the most frequent cyanotoxin produced by Microcystis aeruginosa cyanobacteria in the contaminated freshwater environment. MC represents a health hazard to humans and animals. Therefore, the present study was designed to evaluate the potential ameliorative effect of thymoquin...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2019-01, Vol.2019 (2019), p.1-10
Hauptverfasser:	Alkahtani, Saad, Alkahtane, Abdullah A., Ali, Daoud, Aleya, Lotfi, Abdeen, Ahmed, Sayed, Amany A., Abdel-Daim, Mohamed M., Alarifi, Saud
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Alkaloids - therapeutic use Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants Benzodioxoles - pharmacology Benzodioxoles - therapeutic use Benzoquinones - pharmacology Benzoquinones - therapeutic use Bioavailability Chemical and Drug Induced Liver Injury - drug therapy Cytochrome P-450 Enzyme Inhibitors - pharmacology Cytochrome P-450 Enzyme Inhibitors - therapeutic use Cytokines Dehydrogenases Drug therapy Environmental Sciences Enzymes Free radicals Health aspects Laboratory animals Liver Male Marine toxins Mice Neurotoxicity Neurotoxicity Syndromes - drug therapy Oxidative stress Phosphatase Piperidines - pharmacology Piperidines - therapeutic use Polyunsaturated Alkamides - pharmacology Polyunsaturated Alkamides - therapeutic use Science Toxicology Tumor necrosis factor-TNF
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