MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

Signaling diversity and subsequent complexity in higher eukaryotes is partially explained by one gene encoding a polypeptide with multiple biochemical functions in different cellular contexts. For example, mouse double minute 2 (MDM2) is functionally characterized as both an oncogene and a tumor sup...

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Veröffentlicht in:	Molecular cell 2019-05, Vol.74 (3), p.452-465.e7
Hauptverfasser:	Elkholi, Rana, Abraham-Enachescu, Ioana, Trotta, Andrew P., Rubio-Patiño, Camila, Mohammed, Jarvier N., Luna-Vargas, Mark P.A., Gelles, Jesse D., Kaminetsky, Joshua R., Serasinghe, Madhavika N., Zou, Cindy, Ali, Sumaira, McStay, Gavin P., Pfleger, Cathie M., Chipuk, Jerry Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals apoptosis Apoptosis - genetics BCL-2 family Cell Respiration - genetics complex I Cytosol - metabolism Drosophila melanogaster - genetics Electron Transport Complex I - genetics Humans MDM2 Mice Mice, Transgenic mitochondria Mitochondria - genetics Mitochondria - metabolism NADH Dehydrogenase - genetics NDUFS1 Oxidative Stress - genetics Proto-Oncogene Proteins c-mdm2 - genetics Signal Transduction - genetics Tumor Suppressor Protein p53 - genetics
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