BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress

Several lines of evidence link the canonical oncogene BCL6 to stress response. Here we demonstrate that BCL6 evolved in vertebrates as a component of the HSF1-driven stress response, which has been co-opted by the immune system to support germinal center formation and may have been decisive in the c...

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Veröffentlicht in:	Cancer discovery 2019-05, Vol.9 (5), p.662-679
Hauptverfasser:	Fernando, Tharu M, Marullo, Rossella, Pera Gresely, Benet, Phillip, Jude M, Yang, Shao Ning, Lundell-Smith, Geoffrey, Torregroza, Ingrid, Ahn, Haelee, Evans, Todd, Győrffy, Balázs, Privé, Gilbert G, Hirano, Masayuki, Melnick, Ari M, Cerchietti, Leandro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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