A novel tetrazole analogue of resveratrol is a potent anticancer agent

[Display omitted] •Tetrazolylresveratrols exhibit anti-cancer activity against human cancer cells.•Tetrazolylresveratrols are cytotoxic against MV4-11 cells but not normal cells.•Tetrazolylresveratrols inhibit tubulin polymerization.•Tetrazolylresveratrols interact with the colchicine binding site o...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2019-01, Vol.29 (2), p.172-178
Hauptverfasser:	Bommagani, Shobanbabu, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Kuravi, Sudhakiranmayi, Caldas-Lopes, Eloisi, Guzman, Monica L., Balusu, Ramesh, Crooks, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Antileukemia activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Humans Molecular Structure Structure-Activity Relationship Tetrazole analogues of resveratrol Tetrazoles - chemical synthesis Tetrazoles - chemistry Tetrazoles - pharmacology Tetrazolyl stilbenes Tubulin inhibitors
Online-Zugang:	Volltext
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