Over-expression of cyclin D1 regulates Cdk4 protein synthesis

Increased Cdk4 expression occurs coincident with over-expression of cyclin D1 in many human tumours and tumourigenic mouse models. Here, we investigate both in vivo and in vitro the mechanism by which Cdk4 expression is regulated in the context of cyclin D1 over-expression. Cdk4 mRNA levels in cycli...

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Veröffentlicht in:	Cell proliferation 2003-12, Vol.36 (6), p.347-360
Hauptverfasser:	Parker, M. A., Deane, N. G., Thompson, E. A., Whitehead, R. H., Mithani, S. K., Washington, M. K., Datta, P. K., Dixon, D. A., Beauchamp, R. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Transformed Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - biosynthesis Gene Expression Regulation, Enzymologic Hepatocytes Male Mice Mice, Inbred C57BL Mice, Transgenic Original Proto-Oncogene Proteins RNA, Messenger - metabolism Transduction, Genetic
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