Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B

. The inhibitory action of gangliosides GT1B, GD1A, GM3 and GM1 on cell proliferation and epidermal growth factor receptor (EGFR) phosphorylation was determined in the N‐myc amplified human neuroblastoma cell line NBL‐W. The IC50 of each ganglioside was estimated from concentration‐response regress...

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Veröffentlicht in:	Cell proliferation 2002-04, Vol.35 (2), p.105-115
Hauptverfasser:	Mirkin, B. L., Clark, S. H., Zhang, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrate Sequence Cell Division - drug effects Cell Division - physiology Dogs Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism G(M1) Ganglioside - chemistry G(M1) Ganglioside - metabolism G(M1) Ganglioside - pharmacology G(M3) Ganglioside - chemistry G(M3) Ganglioside - metabolism G(M3) Ganglioside - pharmacology Gangliosides - chemistry Gangliosides - metabolism Gangliosides - pharmacology Humans Molecular Sequence Data Neuroblastoma Original Phosphorylation Structure-Activity Relationship Tumor Cells, Cultured - cytology Tumor Cells, Cultured - metabolism Tyrosine - metabolism
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