IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes

Objectives IFI27 is highly expressed in psoriatic lesions but its function has not been known. The present study aimed to explore its role in proliferation of epidermal keratinocytes. Materials and methods IFI27 knockdown and over‐expression in keratinocytes were used to compare their proliferation,...

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Veröffentlicht in:	Cell proliferation 2015-04, Vol.48 (2), p.187-197
Hauptverfasser:	Hsieh, W.-L., Huang, Y.-H., Wang, T.-M., Ming, Y.-C., Tsai, C.-N., Pang, J.-H. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines Animals Apoptosis - genetics CDC2 Protein Kinase cdc25 Phosphatases - metabolism Cell Proliferation - genetics Cells, Cultured Cyclin A - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinases - biosynthesis Cyclin-Dependent Kinases - metabolism Enzyme Activation Epidermal Growth Factor - pharmacology Humans Imiquimod Keratinocytes - cytology Male Membrane Proteins - biosynthesis Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Multiprotein Complexes - biosynthesis Original Phosphorylation Psoriasis - chemically induced Psoriasis - drug therapy RNA Interference RNA, Small Interfering S Phase Cell Cycle Checkpoints - genetics Skin - cytology Tumor Suppressor Protein p53 - metabolism
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