Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK-dependent manner

Objectives Icariin, a flavonoid isolated from Epimedium pubescens, has previously been identified to exert beneficial effects on preventing bone loss and promoting bone regeneration. However, molecular mechanisms for its anabolic action have, up to now, remained largely unknown. Materials and method...

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Veröffentlicht in:	Cell proliferation 2015-06, Vol.48 (3), p.375-384
Hauptverfasser:	Wu, Yuqiong, Xia, Lunguo, Zhou, Yuning, Xu, Yuanjin, Jiang, Xinquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Anthracenes - pharmacology Bone Density Conservation Agents - pharmacology Cell Differentiation - drug effects Cell Proliferation Collagen Type I - genetics Collagen Type I - metabolism Drugs, Chinese Herbal - pharmacology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Flavonoids - pharmacology Gene Expression Regulation, Developmental Imidazoles - pharmacology JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Male Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Original Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteocalcin - genetics Osteocalcin - metabolism Osteogenesis - drug effects Osteogenesis - genetics Osteopontin - genetics Osteopontin - metabolism p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Primary Cell Culture Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley Signal Transduction
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