A FASII Inhibitor Prevents Staphylococcal Evasion of Daptomycin by Inhibiting Phospholipid Decoy Production

Daptomycin is a treatment of last resort for serious infections caused by drug-resistant Gram-positive pathogens, such as methicillin-resistant We have shown recently that can evade daptomycin by releasing phospholipid decoys that sequester and inactivate the antibiotic, leading to treatment failure...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-04, Vol.63 (4)
Hauptverfasser:	Pee, Carmen J E, Pader, Vera, Ledger, Elizabeth V K, Edwards, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Benzofurans Benzofurans - pharmacology Daptomycin Daptomycin - pharmacology Drug Combinations Fatty Acids - biosynthesis Humans Mechanisms of Action: Physiological Effects Methicillin-Resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Phospholipids Phospholipids - metabolism Pyrones Pyrones - pharmacology Staphylococcal Infections - drug therapy
Online-Zugang:	Volltext
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