Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Using a murine model of bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreate...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-05, Vol.63 (5)
Hauptverfasser:	Rodgers, Aoife M, McCrudden, Maelíosa T C, Courtenay, Aaron J, Kearney, Mary-Carmel, Edwards, Katherine L, Ingram, Rebecca J, Bengoechea, Jose, Donnelly, Ryan F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - therapeutic use Disease Models, Animal Experimental Therapeutics Gentamicins Gentamicins - therapeutic use Klebsiella Infections Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - pathogenicity Mice
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