Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin
Using a murine model of bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreate...
Gespeichert in:
| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2019-05, Vol.63 (5) |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | |
| container_title | Antimicrobial agents and chemotherapy |
| container_volume | 63 |
| creator | Rodgers, Aoife M McCrudden, Maelíosa T C Courtenay, Aaron J Kearney, Mary-Carmel Edwards, Katherine L Ingram, Rebecca J Bengoechea, Jose Donnelly, Ryan F |
| description | Using a murine model of
bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control
infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the
delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection. |
| doi_str_mv | 10.1128/AAC.02612-18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6496091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2190481974</sourcerecordid><originalsourceid>FETCH-LOGICAL-a418t-6994cd06e80bb856c6d69314d03dfe935ebcfce2cb2e5b0089972237190370b33</originalsourceid><addsrcrecordid>eNp1kc9vFCEcxYnR2LV682w4auK0X34MCxeTzaq1aY0e7JkAw7Q0M7DCTJP978u4takHT3zJ--R94T2E3hI4IYTK081mewJUENoQ-QytCCjZiFaJ52gFIETDJfAj9KqUW6j3VsFLdMRAtpISvkJpm-KU04BTjy8Gb0vww2DwLvp5TDEYj89j790UUsQh4u_BeWz3-KqEeI0_h1LScLeMVcjJ5Gz2-KeZ3I0veHE2IS7qma_jGFyIr9GL3gzFv3k4j9HV1y-_tt-ayx9n59vNZWM4kVMjlOKuA-ElWCtb4UQnFCO8A9b1XrHWW9c7T52lvrUAUqk1pWxNFLA1WMaO0aeD7262o-9cfUA2g97lMJq818kE_a8Sw42-TndacCVAkWrw_sEgp9-zL5MeQ3FLONGnuWhaV3FJ1JpX9OMBrRGUkn3_uIaAXjrStSP9pyNNZMU_HHBTRqpv05xjTeJ_7Lun33g0_lsguwfU9ZrP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2190481974</pqid></control><display><type>article</type><title>Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Rodgers, Aoife M ; McCrudden, Maelíosa T C ; Courtenay, Aaron J ; Kearney, Mary-Carmel ; Edwards, Katherine L ; Ingram, Rebecca J ; Bengoechea, Jose ; Donnelly, Ryan F</creator><creatorcontrib>Rodgers, Aoife M ; McCrudden, Maelíosa T C ; Courtenay, Aaron J ; Kearney, Mary-Carmel ; Edwards, Katherine L ; Ingram, Rebecca J ; Bengoechea, Jose ; Donnelly, Ryan F</creatorcontrib><description>Using a murine model of
bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control
infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the
delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.02612-18</identifier><identifier>PMID: 30858214</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Anti-Bacterial Agents - therapeutic use ; Disease Models, Animal ; Experimental Therapeutics ; Gentamicins ; Gentamicins - therapeutic use ; Klebsiella Infections ; Klebsiella Infections - drug therapy ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - pathogenicity ; Mice</subject><ispartof>Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)</ispartof><rights>Copyright © 2019 Rodgers et al.</rights><rights>Copyright © 2019 Rodgers et al. 2019 Rodgers et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-6994cd06e80bb856c6d69314d03dfe935ebcfce2cb2e5b0089972237190370b33</citedby><cites>FETCH-LOGICAL-a418t-6994cd06e80bb856c6d69314d03dfe935ebcfce2cb2e5b0089972237190370b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496091/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496091/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30858214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodgers, Aoife M</creatorcontrib><creatorcontrib>McCrudden, Maelíosa T C</creatorcontrib><creatorcontrib>Courtenay, Aaron J</creatorcontrib><creatorcontrib>Kearney, Mary-Carmel</creatorcontrib><creatorcontrib>Edwards, Katherine L</creatorcontrib><creatorcontrib>Ingram, Rebecca J</creatorcontrib><creatorcontrib>Bengoechea, Jose</creatorcontrib><creatorcontrib>Donnelly, Ryan F</creatorcontrib><title>Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Using a murine model of
bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control
infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the
delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Experimental Therapeutics</subject><subject>Gentamicins</subject><subject>Gentamicins - therapeutic use</subject><subject>Klebsiella Infections</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - pathogenicity</subject><subject>Mice</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9vFCEcxYnR2LV682w4auK0X34MCxeTzaq1aY0e7JkAw7Q0M7DCTJP978u4takHT3zJ--R94T2E3hI4IYTK081mewJUENoQ-QytCCjZiFaJ52gFIETDJfAj9KqUW6j3VsFLdMRAtpISvkJpm-KU04BTjy8Gb0vww2DwLvp5TDEYj89j790UUsQh4u_BeWz3-KqEeI0_h1LScLeMVcjJ5Gz2-KeZ3I0veHE2IS7qma_jGFyIr9GL3gzFv3k4j9HV1y-_tt-ayx9n59vNZWM4kVMjlOKuA-ElWCtb4UQnFCO8A9b1XrHWW9c7T52lvrUAUqk1pWxNFLA1WMaO0aeD7262o-9cfUA2g97lMJq818kE_a8Sw42-TndacCVAkWrw_sEgp9-zL5MeQ3FLONGnuWhaV3FJ1JpX9OMBrRGUkn3_uIaAXjrStSP9pyNNZMU_HHBTRqpv05xjTeJ_7Lun33g0_lsguwfU9ZrP</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Rodgers, Aoife M</creator><creator>McCrudden, Maelíosa T C</creator><creator>Courtenay, Aaron J</creator><creator>Kearney, Mary-Carmel</creator><creator>Edwards, Katherine L</creator><creator>Ingram, Rebecca J</creator><creator>Bengoechea, Jose</creator><creator>Donnelly, Ryan F</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190501</creationdate><title>Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin</title><author>Rodgers, Aoife M ; McCrudden, Maelíosa T C ; Courtenay, Aaron J ; Kearney, Mary-Carmel ; Edwards, Katherine L ; Ingram, Rebecca J ; Bengoechea, Jose ; Donnelly, Ryan F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-6994cd06e80bb856c6d69314d03dfe935ebcfce2cb2e5b0089972237190370b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Experimental Therapeutics</topic><topic>Gentamicins</topic><topic>Gentamicins - therapeutic use</topic><topic>Klebsiella Infections</topic><topic>Klebsiella Infections - drug therapy</topic><topic>Klebsiella Infections - microbiology</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - pathogenicity</topic><topic>Mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodgers, Aoife M</creatorcontrib><creatorcontrib>McCrudden, Maelíosa T C</creatorcontrib><creatorcontrib>Courtenay, Aaron J</creatorcontrib><creatorcontrib>Kearney, Mary-Carmel</creatorcontrib><creatorcontrib>Edwards, Katherine L</creatorcontrib><creatorcontrib>Ingram, Rebecca J</creatorcontrib><creatorcontrib>Bengoechea, Jose</creatorcontrib><creatorcontrib>Donnelly, Ryan F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodgers, Aoife M</au><au>McCrudden, Maelíosa T C</au><au>Courtenay, Aaron J</au><au>Kearney, Mary-Carmel</au><au>Edwards, Katherine L</au><au>Ingram, Rebecca J</au><au>Bengoechea, Jose</au><au>Donnelly, Ryan F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>63</volume><issue>5</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>Using a murine model of
bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control
infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the
delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>30858214</pmid><doi>10.1128/AAC.02612-18</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5) |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6496091 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Anti-Bacterial Agents - therapeutic use Disease Models, Animal Experimental Therapeutics Gentamicins Gentamicins - therapeutic use Klebsiella Infections Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - pathogenicity Mice |
| title | Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T14%3A52%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Control%20of%20Klebsiella%20pneumoniae%20Infection%20in%20Mice%20by%20Using%20Dissolving%20Microarray%20Patches%20Containing%20Gentamicin&rft.jtitle=Antimicrobial%20agents%20and%20chemotherapy&rft.au=Rodgers,%20Aoife%20M&rft.date=2019-05-01&rft.volume=63&rft.issue=5&rft.issn=0066-4804&rft.eissn=1098-6596&rft_id=info:doi/10.1128/AAC.02612-18&rft_dat=%3Cproquest_pubme%3E2190481974%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2190481974&rft_id=info:pmid/30858214&rfr_iscdi=true |