A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance
The convergence of hypervirulence and multidrug resistance in is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR) isolates. We identified one hypermucoviscous...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2019-05, Vol.63 (5) |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Wozniak, Jessie E Band, Victor I Conley, Andrew B Rishishwar, Lavanya Burd, Eileen M Satola, Sarah W Hardy, Dwight J Tsay, Rebecca Farley, Monica M Jacob, Jesse T Dumyati, Ghinwa Jordan, I King Weiss, David S |
| description | The convergence of hypervirulence and multidrug resistance in
is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR)
isolates. We identified one hypermucoviscous isolate, which carried a gene encoding the KPC-3 carbapenemase, among numerous resistance genes. The strain further exhibited colistin heteroresistance undetected by diagnostics. This convergence of diverse resistance mechanisms and increased virulence underscores the need for enhanced
surveillance. |
| doi_str_mv | 10.1128/AAC.00107-19 |
| format | Article |
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is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR)
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is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem-resistant (CR)
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surveillance.</description><subject>Carbapenem-Resistant Enterobacteriaceae</subject><subject>Carbapenem-Resistant Enterobacteriaceae - drug effects</subject><subject>Carbapenem-Resistant Enterobacteriaceae - genetics</subject><subject>Carbapenems</subject><subject>Carbapenems - pharmacology</subject><subject>Colistin</subject><subject>Colistin - pharmacology</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Epidemiology and Surveillance</subject><subject>Genotype</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Virulence</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFv1DAQhS0Eokvhxhn5CBIpduI4yQVpFRVaUYFUKFdr4kxYV469tZ1W_Tf9qXXZpYIDJ489n96T3yPkNWdHnJfth_W6P2KMs6bg3ROy4qxrC1l38ilZMSZlIVomDsiLGC9Zvtcde04OKtayqpNyRe7W9Csk492NGZF-1wHRUT_RHsIAW3Q4F-cYTUzgEv1icYgGrQW6dbjM3hlAeo7XCDZScPQ0egsJ6Y1JG3rsNuA0jvSnCYvFPGZkpL01zmiw9pZeuBET6pSZ3ttsYhw9yS_Bh72nxpfk2ZTV8dX-PCQXn45_9CfF2bfPp_36rADB21RULbYDCs6mpoOa1x2KcuCSTbqTwEA0rJRlhUMNzQQj6BydGBuuB40wlVJXh-TjTne7DDOOGl0KYNU2mBnCrfJg1L8bZzbql79WUnSStSILvN0LBH-1YExqNlE_hOXQL1GVvJVc1JyVGX2_Q3XwMQacHm04Uw-lqlyq-l2q4l3G3-1wiHOpLv0SXE7if-ybv7_xKPyn8eoe6beuFg</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Wozniak, Jessie E</creator><creator>Band, Victor I</creator><creator>Conley, Andrew B</creator><creator>Rishishwar, Lavanya</creator><creator>Burd, Eileen M</creator><creator>Satola, Sarah W</creator><creator>Hardy, Dwight J</creator><creator>Tsay, Rebecca</creator><creator>Farley, Monica M</creator><creator>Jacob, Jesse T</creator><creator>Dumyati, Ghinwa</creator><creator>Jordan, I King</creator><creator>Weiss, David S</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9811-6260</orcidid><orcidid>https://orcid.org/0000-0003-0980-7866</orcidid></search><sort><creationdate>20190501</creationdate><title>A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance</title><author>Wozniak, Jessie E ; Band, Victor I ; Conley, Andrew B ; Rishishwar, Lavanya ; Burd, Eileen M ; Satola, Sarah W ; Hardy, Dwight J ; Tsay, Rebecca ; Farley, Monica M ; Jacob, Jesse T ; Dumyati, Ghinwa ; Jordan, I King ; Weiss, David S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-38e8be410f79a5159e42b160fc96a0a4702623eb5a7fadac1124d71cbceaf26c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Carbapenem-Resistant Enterobacteriaceae</topic><topic>Carbapenem-Resistant Enterobacteriaceae - drug effects</topic><topic>Carbapenem-Resistant Enterobacteriaceae - genetics</topic><topic>Carbapenems</topic><topic>Carbapenems - pharmacology</topic><topic>Colistin</topic><topic>Colistin - pharmacology</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Epidemiology and Surveillance</topic><topic>Genotype</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wozniak, Jessie E</creatorcontrib><creatorcontrib>Band, Victor I</creatorcontrib><creatorcontrib>Conley, Andrew B</creatorcontrib><creatorcontrib>Rishishwar, Lavanya</creatorcontrib><creatorcontrib>Burd, Eileen M</creatorcontrib><creatorcontrib>Satola, Sarah W</creatorcontrib><creatorcontrib>Hardy, Dwight J</creatorcontrib><creatorcontrib>Tsay, Rebecca</creatorcontrib><creatorcontrib>Farley, Monica M</creatorcontrib><creatorcontrib>Jacob, Jesse T</creatorcontrib><creatorcontrib>Dumyati, Ghinwa</creatorcontrib><creatorcontrib>Jordan, I King</creatorcontrib><creatorcontrib>Weiss, David S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wozniak, Jessie E</au><au>Band, Victor I</au><au>Conley, Andrew B</au><au>Rishishwar, Lavanya</au><au>Burd, Eileen M</au><au>Satola, Sarah W</au><au>Hardy, Dwight J</au><au>Tsay, Rebecca</au><au>Farley, Monica M</au><au>Jacob, Jesse T</au><au>Dumyati, Ghinwa</au><au>Jordan, I King</au><au>Weiss, David S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>63</volume><issue>5</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>The convergence of hypervirulence and multidrug resistance in
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| ispartof | Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5) |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Carbapenem-Resistant Enterobacteriaceae Carbapenem-Resistant Enterobacteriaceae - drug effects Carbapenem-Resistant Enterobacteriaceae - genetics Carbapenems Carbapenems - pharmacology Colistin Colistin - pharmacology Drug Resistance, Bacterial - genetics Epidemiology and Surveillance Genotype Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Microbial Sensitivity Tests Virulence |
| title | A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance |
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