TGF-β signalling prevents pancreatic beta cell death after proliferation

Objectives Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor‐beta (TGF‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post‐natal beta cell growth has only been rece...

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Veröffentlicht in:	Cell proliferation 2015-06, Vol.48 (3), p.356-362
Hauptverfasser:	Lei, Chen, Zhou, Xiaoling, Pang, Yi, Mao, Yuanyuan, Lu, Xixuan, Li, Meijuan, Zhang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Count Cell Proliferation Gene Expression Regulation Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Mice Mice, Transgenic Mutation Original Pancreatectomy Regeneration Signal Transduction - genetics T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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