TGF-β signalling prevents pancreatic beta cell death after proliferation
Objectives Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor‐beta (TGF‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post‐natal beta cell growth has only been rece...
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| Veröffentlicht in: | Cell proliferation 2015-06, Vol.48 (3), p.356-362 |
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| container_title | Cell proliferation |
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| creator | Lei, Chen Zhou, Xiaoling Pang, Yi Mao, Yuanyuan Lu, Xixuan Li, Meijuan Zhang, Jie |
| description | Objectives
Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor‐beta (TGF‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post‐natal beta cell growth has only been recently reported.
Materials and methods
Here, we studied the role of TGF‐β receptor signalling in beta cell proliferation after 50% partial pancreatectomy (PPx), using beta cell‐specific TGF‐β receptor II (TBR2)‐mutated mice.
Results
Consistent with previous reports, we found that inhibition of TGF‐β receptor signalling in beta cells resulted in slightly higher beta cell mass 1 week after PPx, due to greater beta cell proliferation. However, beta cell mass in these beta cell‐specific TBR2‐mutated mice significantly decreased by 12 weeks after PPx, resulting from increase in beta cell apoptosis.
Conclusions
Our data thus suggest that TGF‐β receptor signalling may be required for prevention of beta cell death after proliferation, and highlight this pathway as an essential regulator during post‐natal beta cell homoeostasis. |
| doi_str_mv | 10.1111/cpr.12183 |
| format | Article |
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Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor‐beta (TGF‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post‐natal beta cell growth has only been recently reported.
Materials and methods
Here, we studied the role of TGF‐β receptor signalling in beta cell proliferation after 50% partial pancreatectomy (PPx), using beta cell‐specific TGF‐β receptor II (TBR2)‐mutated mice.
Results
Consistent with previous reports, we found that inhibition of TGF‐β receptor signalling in beta cells resulted in slightly higher beta cell mass 1 week after PPx, due to greater beta cell proliferation. However, beta cell mass in these beta cell‐specific TBR2‐mutated mice significantly decreased by 12 weeks after PPx, resulting from increase in beta cell apoptosis.
Conclusions
Our data thus suggest that TGF‐β receptor signalling may be required for prevention of beta cell death after proliferation, and highlight this pathway as an essential regulator during post‐natal beta cell homoeostasis.</description><identifier>ISSN: 0960-7722</identifier><identifier>EISSN: 1365-2184</identifier><identifier>DOI: 10.1111/cpr.12183</identifier><identifier>PMID: 25871744</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Apoptosis ; Cell Count ; Cell Proliferation ; Gene Expression Regulation ; Insulin-Secreting Cells - cytology ; Insulin-Secreting Cells - metabolism ; Mice ; Mice, Transgenic ; Mutation ; Original ; Pancreatectomy ; Regeneration ; Signal Transduction - genetics ; T-Box Domain Proteins - genetics ; T-Box Domain Proteins - metabolism ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - metabolism</subject><ispartof>Cell proliferation, 2015-06, Vol.48 (3), p.356-362</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5233-7eb83c232f1dee6c67b0e733843c642f25cfa5d2d407e5ed3351085d9415f0503</citedby><cites>FETCH-LOGICAL-c5233-7eb83c232f1dee6c67b0e733843c642f25cfa5d2d407e5ed3351085d9415f0503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496026/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496026/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,27922,27923,45572,45573,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25871744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lei, Chen</creatorcontrib><creatorcontrib>Zhou, Xiaoling</creatorcontrib><creatorcontrib>Pang, Yi</creatorcontrib><creatorcontrib>Mao, Yuanyuan</creatorcontrib><creatorcontrib>Lu, Xixuan</creatorcontrib><creatorcontrib>Li, Meijuan</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><title>TGF-β signalling prevents pancreatic beta cell death after proliferation</title><title>Cell proliferation</title><addtitle>Cell Prolif</addtitle><description>Objectives
Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor‐beta (TGF‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post‐natal beta cell growth has only been recently reported.
Materials and methods
Here, we studied the role of TGF‐β receptor signalling in beta cell proliferation after 50% partial pancreatectomy (PPx), using beta cell‐specific TGF‐β receptor II (TBR2)‐mutated mice.
Results
Consistent with previous reports, we found that inhibition of TGF‐β receptor signalling in beta cells resulted in slightly higher beta cell mass 1 week after PPx, due to greater beta cell proliferation. However, beta cell mass in these beta cell‐specific TBR2‐mutated mice significantly decreased by 12 weeks after PPx, resulting from increase in beta cell apoptosis.
Conclusions
Our data thus suggest that TGF‐β receptor signalling may be required for prevention of beta cell death after proliferation, and highlight this pathway as an essential regulator during post‐natal beta cell homoeostasis.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cell Count</subject><subject>Cell Proliferation</subject><subject>Gene Expression Regulation</subject><subject>Insulin-Secreting Cells - cytology</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mutation</subject><subject>Original</subject><subject>Pancreatectomy</subject><subject>Regeneration</subject><subject>Signal Transduction - genetics</subject><subject>T-Box Domain Proteins - genetics</subject><subject>T-Box Domain Proteins - metabolism</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0960-7722</issn><issn>1365-2184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAQhi0EgrIceAGUIxwCXuKlFySooCAhNhXBzXKdSTGkSbBTltfiQXgmXAoVHPDFlv3NP-MPoU2Cd0lce7bxu4QSxRZQhzDB03jOFlEHdwVOpaR0Ba2G8IAxYUSKZbRCuZJEZlkHnQ76x-nHexLcqDJl6apR0nh4hqoNSWMq68G0ziZDaE1ioSyTPF7cJ6ZowUeyLl0BPiJ1tY6WClMG2Pje19DN8dGgd5KeXfRPewdnqeWUsVTCUDFLGS1IDiCskEMMkjGVMSsyWlBuC8NzmmdYAoecMU6w4nk3I7zAHLM1tD_LbSbDMeQ2jupNqRvvxsa_6do4_felcvd6VD9rkUUdVMSA7e8AXz9NILR67ML0b6aCehI0EQqTLpVq2mtnhlpfh-ChmLchWE_V66hef6mP7Nbvuebkj-sI7M2AF1fC2_9Jund5_ROZzipcaOF1XmH8oxaSSa5vz_v67vDqUqnerR6wT_4Pnio</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Lei, Chen</creator><creator>Zhou, Xiaoling</creator><creator>Pang, Yi</creator><creator>Mao, Yuanyuan</creator><creator>Lu, Xixuan</creator><creator>Li, Meijuan</creator><creator>Zhang, Jie</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201506</creationdate><title>TGF-β signalling prevents pancreatic beta cell death after proliferation</title><author>Lei, Chen ; Zhou, Xiaoling ; Pang, Yi ; Mao, Yuanyuan ; Lu, Xixuan ; Li, Meijuan ; Zhang, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5233-7eb83c232f1dee6c67b0e733843c642f25cfa5d2d407e5ed3351085d9415f0503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cell Count</topic><topic>Cell Proliferation</topic><topic>Gene Expression Regulation</topic><topic>Insulin-Secreting Cells - cytology</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Mutation</topic><topic>Original</topic><topic>Pancreatectomy</topic><topic>Regeneration</topic><topic>Signal Transduction - genetics</topic><topic>T-Box Domain Proteins - genetics</topic><topic>T-Box Domain Proteins - metabolism</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lei, Chen</creatorcontrib><creatorcontrib>Zhou, Xiaoling</creatorcontrib><creatorcontrib>Pang, Yi</creatorcontrib><creatorcontrib>Mao, Yuanyuan</creatorcontrib><creatorcontrib>Lu, Xixuan</creatorcontrib><creatorcontrib>Li, Meijuan</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell proliferation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lei, Chen</au><au>Zhou, Xiaoling</au><au>Pang, Yi</au><au>Mao, Yuanyuan</au><au>Lu, Xixuan</au><au>Li, Meijuan</au><au>Zhang, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TGF-β signalling prevents pancreatic beta cell death after proliferation</atitle><jtitle>Cell proliferation</jtitle><addtitle>Cell Prolif</addtitle><date>2015-06</date><risdate>2015</risdate><volume>48</volume><issue>3</issue><spage>356</spage><epage>362</epage><pages>356-362</pages><issn>0960-7722</issn><eissn>1365-2184</eissn><abstract>Objectives
Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor‐beta (TGF‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post‐natal beta cell growth has only been recently reported.
Materials and methods
Here, we studied the role of TGF‐β receptor signalling in beta cell proliferation after 50% partial pancreatectomy (PPx), using beta cell‐specific TGF‐β receptor II (TBR2)‐mutated mice.
Results
Consistent with previous reports, we found that inhibition of TGF‐β receptor signalling in beta cells resulted in slightly higher beta cell mass 1 week after PPx, due to greater beta cell proliferation. However, beta cell mass in these beta cell‐specific TBR2‐mutated mice significantly decreased by 12 weeks after PPx, resulting from increase in beta cell apoptosis.
Conclusions
Our data thus suggest that TGF‐β receptor signalling may be required for prevention of beta cell death after proliferation, and highlight this pathway as an essential regulator during post‐natal beta cell homoeostasis.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25871744</pmid><doi>10.1111/cpr.12183</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals; PubMed Central |
| subjects | Animals Apoptosis Cell Count Cell Proliferation Gene Expression Regulation Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Mice Mice, Transgenic Mutation Original Pancreatectomy Regeneration Signal Transduction - genetics T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism |
| title | TGF-β signalling prevents pancreatic beta cell death after proliferation |
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