MnTM‐4‐PyP Modulates Endogenous Antioxidant Responses and Protects Primary Cortical Neurons against Oxidative Stress

Summary Aims Oxidative stress is a direct cause of injury in various neural diseases. Manganese porphyrins (MnPs), a large category of superoxide dismutase (SOD) mimics, shown universally to have effects in numerous neural disease models in vivo. Given their complex intracellular redox activities, d...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2015-05, Vol.21 (5), p.435-445
Hauptverfasser:	Cheng, Kuo‐Yuan, Guo, Fei, Lu, Jia‐Qi, Cao, Yuan‐Zhao, Wang, Tian‐Chang, Yang, Qi, Xia, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - metabolism Catalase - metabolism Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - physiology Endogenous antioxidant response Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Hydrogen Peroxide - toxicity Manganese - metabolism Manganese porphyrin Metalloporphyrins - chemistry Metalloporphyrins - pharmacology Mitochondria - drug effects Mitochondria - physiology MnTM‐4‐PyP Neurons Neurons - drug effects Neurons - physiology Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Original Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Sirt3 Superoxide dismutase
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