TEAD1 (TEA Domain Transcription Factor 1) Promotes Smooth Muscle Cell Proliferation Through Upregulating SLC1A5 (Solute Carrier Family 1 Member 5)-Mediated Glutamine Uptake

RATIONALE:TEAD (TEA domain transcription factor) 1—a major effector of the Hippo signaling pathway—acts as an oncoprotein in a variety of tumors. However, the function of TEAD1 in vascular smooth muscle cells (VSMCs) remains unclear. OBJECTIVE:To assess the role of TEAD1 in vascular injury–induced s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2019-04, Vol.124 (9), p.1309-1322
Hauptverfasser:	Osman, Islam, He, Xiangqin, Liu, Jinhua, Dong, Kunzhe, Wen, Tong, Zhang, Fanzhi, Yu, Luyi, Hu, Guoqing, Xin, Hongbo, Zhang, Wei, Zhou, Jiliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System ASC - genetics Amino Acid Transport System ASC - metabolism Animals Biological Transport - genetics Cell Proliferation Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Glutamine - metabolism Humans Mechanistic Target of Rapamycin Complex 1 - metabolism Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Minor Histocompatibility Antigens - genetics Minor Histocompatibility Antigens - metabolism Molecular Medicine Myocytes, Smooth Muscle - metabolism Neointima - genetics Neointima - metabolism RNA Interference Signal Transduction TEA Domain Transcription Factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!