Possible Involvement of Monoaminergic Neurotransmission in Antidepressant-like activity of Emblica officinalis Fruits in Mice

SUMMARY Aims: In this study, antidepressant‐like activity of Emblica offcinalis Gaertn. fruits (Family: Euphorbiaceae) was evaluated in Swiss young male albino mice employing tail suspension test and forced swim test. Methods: Aqueous extract (200 and 400 mg/kg) of the fruits was administered orally...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2012-05, Vol.18 (5), p.419-425
Hauptverfasser:	Dhingra, Dinesh, Joshi, Parul, Gupta, Arun, Chhillar, Ritu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Adult and adolescent clinical studies alpha 1-Adrenergic receptors Amine oxidase (flavin-containing) Animals Antidepressants Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Antioxidants Ascorbic acid Ascorbic Acid - metabolism Baclofen Biogenic Monoamines - metabolism Biological and medical sciences Brain Central nervous system Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression Depression - drug therapy Depression - metabolism Depression - physiopathology Disease Models, Animal Dopamine D2 receptors Dose-Response Relationship, Drug Drug dosages Emblica officinalis Enzymes Euphorbiaceae Fluoxetine Forced swim test Fruit - chemistry Fruits GABA gamma -Aminobutyric acid B receptors gamma-Aminobutyric Acid - metabolism Hindlimb Suspension - methods Hydrochloric acid Imipramine Intellectual deficiency Laboratories Locomotor activity Male MAO Medical sciences Mental depression Mice Monoamine Oxidase - metabolism Mood disorders Motor Activity - drug effects Nervous system Neurology Neurotransmission Oral administration Original Phyllanthus emblica Phytotherapy Plant Preparations - chemistry Plant Preparations - therapeutic use Prazosin Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin Serotonin receptors Sulpiride Swimming Swimming - psychology Tail suspension test Time Factors Tryptophan Tryptophan hydroxylase γ-Aminobutyric acid B receptors
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