Edaravone Protects HT22 Neurons from H2O2‐induced Apoptosis by Inhibiting the MAPK Signaling Pathway

Summary Aims Oxidative stress is frequently implicated in the pathology of neurodegenerative diseases. This study aimed to investigate the effects and their underlying mechanism(s) of edaravone upon hydrogen peroxide (H2O2)–induced oxidative stress and apoptosis in HT22 cells, a murine hippocampal n...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2013-03, Vol.19 (3), p.163-169
Hauptverfasser:	Zhao, Zhong‐Yan, Luan, Ping, Huang, Shi‐Xiong, Xiao, Song‐Hua, Zhao, Jia, Zhang, Bei, Gu, Bei‐Bei, Pi, Rong‐Biao, Liu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antioxidants Antipyrine - analogs & derivatives Antipyrine - pharmacology Apoptosis Apoptosis - drug effects Bax protein Bcl-2 protein Biological and medical sciences Cell injury Cell Survival - drug effects Cells Cells, Cultured Central nervous system Cytotoxicity Development. Senescence. Regeneration. Transplantation Drug toxicity and drugs side effects treatment Edaravone Flow cytometry Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - pathology HT22 cells Hydrogen peroxide Hydrogen Peroxide - pharmacology Injuries MAP kinase MAP Kinase Signaling System - drug effects Medical sciences Mice Nervous system Neurodegenerative diseases Neurons Neurons - drug effects Neurons - pathology Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Neuroprotective effect Original Oxidative stress Pharmacology. Drug treatments Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Toxicity: nervous system and muscle Vertebrates: nervous system and sense organs
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