Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor‐κB and NLRP3 Inflammasome Activation

Summary Background The activation of nuclear factor‐kappa B (NF‐κB) and NLRP3 inflammasome is involved in neuroinflammation, which is closely linked to Alzheimer's disease (AD). In vivo and in vitro studies have suggested that artemisinin shows antiinflammatory effects in inflammation‐related d...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2013-04, Vol.19 (4), p.262-268
Hauptverfasser:	Shi, Jian‐Quan, Zhang, Chu‐Chu, Sun, Xiu‐Lan, Cheng, Xin‐Xin, Wang, Jiang‐Bo, Zhang, Ying‐Dong, Xu, Jun, Zou, Hai‐Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - prevention & control Amyloid beta Amyloid beta-Protein Precursor - genetics Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Antimalarials - pharmacology Antimalarials - therapeutic use Artemisinin Artemisinins - pharmacology Artemisinins - therapeutic use BACE1 Biological and medical sciences Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Inflammasomes - antagonists & inhibitors Inflammasomes - metabolism Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Medical sciences Mice Mice, Transgenic NALP3 inflammasome Neurology Neurons - metabolism Neurons - pathology Neuropharmacology Neuroprotective agent NF-kappa B - antagonists & inhibitors NF-kappa B - physiology NF‐κB NLR Family, Pyrin Domain-Containing 3 Protein Original Pharmacology. Drug treatments Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Plaque, Amyloid - prevention & control Presenilin-1 - genetics Up-Regulation - drug effects Up-Regulation - genetics
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