Genomic evolution of cancer models: perils and opportunities

Cancer research relies on model systems, which reflect the biology of actual human tumours to only a certain extent. One important feature of human cancer is its intra-tumour genomic heterogeneity and instability. However, the extent of such genomic instability in cancer models has received limited...

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Veröffentlicht in:	Nature reviews. Cancer 2019-02, Vol.19 (2), p.97-109
Hauptverfasser:	Ben-David, Uri, Beroukhim, Rameen, Golub, Todd R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212/2304 631/67/68 631/67/69 631/67/70 Animals Biomedical and Life Sciences Biomedicine Cancer Cancer genetics Cancer Research Cancer treatment Evolution, Molecular Genetic Heterogeneity Genomic instability Genomic Instability - genetics Genomics - methods Genotypes Heterogeneity Humans Medical research Neoplasms - genetics Perspective Precision medicine Precision Medicine - methods Properties Tumors
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