Allosteric Modulation of Sigma‐1 Receptors Elicits Rapid Antidepressant Activity

Summary Aims Sigma‐1 receptors are involved in the pathophysiological process of several neuropsychiatric diseases such as epilepsy, depression. Allosteric modulation represents an important mechanism for receptor functional regulation. In this study, we examined antidepressant activity of the lates...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2016-05, Vol.22 (5), p.368-377
Hauptverfasser:	Wang, Yun, Guo, Lin, Jiang, Hua‐Feng, Zheng, Long‐Tai, Zhang, Ao, Zhen, Xue‐Chu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric modulation Animals Antidepressant Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Antipsychotic Agents - pharmacology Anxiety - drug therapy Anxiety - etiology Benzazepines - pharmacology Benzazepines - therapeutic use Brain-Derived Neurotrophic Factor - pharmacology Brain‐derived neurotrophic factor Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Embryo, Mammalian Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Glycogen synthase kinase 3β Hippocampus - cytology Immobility Response, Tonic - drug effects Male Mice Mice, Inbred C57BL Neurons - cytology Neurons - drug effects Neurons - metabolism Original Phenazocine - analogs & derivatives Phenazocine - pharmacology Receptors, sigma - metabolism Sigma-1 Receptor Sigma‐1 receptors Signal Transduction - drug effects Stress, Psychological - complications Stress, Psychological - drug therapy Swimming - psychology Time Factors Venlafaxine Hydrochloride - pharmacology Venlafaxine Hydrochloride - therapeutic use
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