Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice
Summary Introduction We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless‐like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain un...
Gespeichert in:
| Veröffentlicht in: | CNS neuroscience & therapeutics 2017-02, Vol.23 (2), p.119-126 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 126 |
|---|---|
| container_issue | 2 |
| container_start_page | 119 |
| container_title | CNS neuroscience & therapeutics |
| container_volume | 23 |
| creator | Fonseca, Raquel Carvalho, Rui A. Lemos, Cristina Sequeira, Ana C. Pita, Inês R. Carvalho, Fábio Silva, Carlos D. Prediger, Rui D. S. Jarak, Ivana Cunha, Rodrigo A. Fontes Ribeiro, Carlos A. Köfalvi, Attila Pereira, Frederico C. |
| description | Summary
Introduction
We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless‐like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown.
Aims
Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety‐related phenotypes 3 days postinjection.
Results
Methamphetamine induced depressive‐like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety‐like behavior or motor functions. Depolarization‐induced glucose uptake was reduced in frontocortical slices from METH‐treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N‐acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex.
Conclusions
We report, for the first time, that a single METH injection triggers early self‐care and hedonic deficits and impairs frontal cortical energetics in mice. |
| doi_str_mv | 10.1111/cns.12649 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6492743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4301989981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4769-606f966720632174491009a88454629bb11f2763d0b910d558317109435a8c8e3</originalsourceid><addsrcrecordid>eNqFkc1uEzEUhS0Eoj-w4AWQJTawSGt7_LtBKlELkVJYAGvL8dx0XGbs1J4p6q6PwDPyJLikRICEsBc-0v10dH0OQs8oOaL1HPtYjiiT3DxA-1QJMROGm4c73ZA9dFDKJSGSaaMfoz2mlGREmX3kzmHs3LDpYHRDiIAXsZ08FHwSO2hTDP777bdl-AL4DXTuOqSMXWzxYti4kAs-yymOrsfzlMfgqziNkC-g6oJDxOfBwxP0aO36Ak_v30P0-ez00_zdbPnh7WJ-spx5rqSZSSLXRkrFiGwYVZwbSohxWnPBJTOrFaVrpmTTklWdtELohipKDG-E015Dc4heb30302qA1kMcs-vtJofB5RubXLB_TmLo7EW6tjU3pnhTDV7eG-R0NUEZ7RCKh753EdJULNVSNzXlusT_0UYIcpdxRV_8hV6mKceaRKVEvZwIXqlXW8rnVEqG9W5vSuxdx7Z2bH92XNnnv390R_4qtQLHW-Br6OHm3052_v7j1vIH2Iivag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1858584054</pqid></control><display><type>article</type><title>Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice</title><source>Wiley Open Access</source><creator>Fonseca, Raquel ; Carvalho, Rui A. ; Lemos, Cristina ; Sequeira, Ana C. ; Pita, Inês R. ; Carvalho, Fábio ; Silva, Carlos D. ; Prediger, Rui D. S. ; Jarak, Ivana ; Cunha, Rodrigo A. ; Fontes Ribeiro, Carlos A. ; Köfalvi, Attila ; Pereira, Frederico C.</creator><creatorcontrib>Fonseca, Raquel ; Carvalho, Rui A. ; Lemos, Cristina ; Sequeira, Ana C. ; Pita, Inês R. ; Carvalho, Fábio ; Silva, Carlos D. ; Prediger, Rui D. S. ; Jarak, Ivana ; Cunha, Rodrigo A. ; Fontes Ribeiro, Carlos A. ; Köfalvi, Attila ; Pereira, Frederico C.</creatorcontrib><description>Summary
Introduction
We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless‐like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown.
Aims
Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety‐related phenotypes 3 days postinjection.
Results
Methamphetamine induced depressive‐like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety‐like behavior or motor functions. Depolarization‐induced glucose uptake was reduced in frontocortical slices from METH‐treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N‐acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex.
Conclusions
We report, for the first time, that a single METH injection triggers early self‐care and hedonic deficits and impairs frontal cortical energetics in mice.</description><identifier>ISSN: 1755-5930</identifier><identifier>EISSN: 1755-5949</identifier><identifier>DOI: 10.1111/cns.12649</identifier><identifier>PMID: 27762079</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Anhedonia - drug effects ; Animals ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Brain Injuries - chemically induced ; Brain Injuries - pathology ; Central Nervous System Stimulants - toxicity ; Cerebral Cortex - drug effects ; Cerebral Cortex - pathology ; Depressive‐like behavior ; Disease Models, Animal ; Exploratory Behavior - drug effects ; Food Preferences - drug effects ; Frontal cortex ; Glucose - metabolism ; Glucose Transporter Type 1 - metabolism ; Glucose Transporter Type 3 - metabolism ; Glutamic Acid - metabolism ; Grooming - drug effects ; Male ; Maze Learning - drug effects ; Metabolism ; Methamphetamine ; Methamphetamine - toxicity ; Mice ; Mice, Inbred C57BL ; Motor Activity - drug effects ; Original ; Rodents</subject><ispartof>CNS neuroscience & therapeutics, 2017-02, Vol.23 (2), p.119-126</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4769-606f966720632174491009a88454629bb11f2763d0b910d558317109435a8c8e3</citedby><cites>FETCH-LOGICAL-c4769-606f966720632174491009a88454629bb11f2763d0b910d558317109435a8c8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492743/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492743/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,11560,27922,27923,45572,45573,46050,46474,53789,53791</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcns.12649$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27762079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fonseca, Raquel</creatorcontrib><creatorcontrib>Carvalho, Rui A.</creatorcontrib><creatorcontrib>Lemos, Cristina</creatorcontrib><creatorcontrib>Sequeira, Ana C.</creatorcontrib><creatorcontrib>Pita, Inês R.</creatorcontrib><creatorcontrib>Carvalho, Fábio</creatorcontrib><creatorcontrib>Silva, Carlos D.</creatorcontrib><creatorcontrib>Prediger, Rui D. S.</creatorcontrib><creatorcontrib>Jarak, Ivana</creatorcontrib><creatorcontrib>Cunha, Rodrigo A.</creatorcontrib><creatorcontrib>Fontes Ribeiro, Carlos A.</creatorcontrib><creatorcontrib>Köfalvi, Attila</creatorcontrib><creatorcontrib>Pereira, Frederico C.</creatorcontrib><title>Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice</title><title>CNS neuroscience & therapeutics</title><addtitle>CNS Neurosci Ther</addtitle><description>Summary
Introduction
We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless‐like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown.
Aims
Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety‐related phenotypes 3 days postinjection.
Results
Methamphetamine induced depressive‐like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety‐like behavior or motor functions. Depolarization‐induced glucose uptake was reduced in frontocortical slices from METH‐treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N‐acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex.
Conclusions
We report, for the first time, that a single METH injection triggers early self‐care and hedonic deficits and impairs frontal cortical energetics in mice.</description><subject>Anhedonia - drug effects</subject><subject>Animals</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Brain Injuries - chemically induced</subject><subject>Brain Injuries - pathology</subject><subject>Central Nervous System Stimulants - toxicity</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - pathology</subject><subject>Depressive‐like behavior</subject><subject>Disease Models, Animal</subject><subject>Exploratory Behavior - drug effects</subject><subject>Food Preferences - drug effects</subject><subject>Frontal cortex</subject><subject>Glucose - metabolism</subject><subject>Glucose Transporter Type 1 - metabolism</subject><subject>Glucose Transporter Type 3 - metabolism</subject><subject>Glutamic Acid - metabolism</subject><subject>Grooming - drug effects</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Metabolism</subject><subject>Methamphetamine</subject><subject>Methamphetamine - toxicity</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Motor Activity - drug effects</subject><subject>Original</subject><subject>Rodents</subject><issn>1755-5930</issn><issn>1755-5949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0Eoj-w4AWQJTawSGt7_LtBKlELkVJYAGvL8dx0XGbs1J4p6q6PwDPyJLikRICEsBc-0v10dH0OQs8oOaL1HPtYjiiT3DxA-1QJMROGm4c73ZA9dFDKJSGSaaMfoz2mlGREmX3kzmHs3LDpYHRDiIAXsZ08FHwSO2hTDP777bdl-AL4DXTuOqSMXWzxYti4kAs-yymOrsfzlMfgqziNkC-g6oJDxOfBwxP0aO36Ak_v30P0-ez00_zdbPnh7WJ-spx5rqSZSSLXRkrFiGwYVZwbSohxWnPBJTOrFaVrpmTTklWdtELohipKDG-E015Dc4heb30302qA1kMcs-vtJofB5RubXLB_TmLo7EW6tjU3pnhTDV7eG-R0NUEZ7RCKh753EdJULNVSNzXlusT_0UYIcpdxRV_8hV6mKceaRKVEvZwIXqlXW8rnVEqG9W5vSuxdx7Z2bH92XNnnv390R_4qtQLHW-Br6OHm3052_v7j1vIH2Iivag</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Fonseca, Raquel</creator><creator>Carvalho, Rui A.</creator><creator>Lemos, Cristina</creator><creator>Sequeira, Ana C.</creator><creator>Pita, Inês R.</creator><creator>Carvalho, Fábio</creator><creator>Silva, Carlos D.</creator><creator>Prediger, Rui D. S.</creator><creator>Jarak, Ivana</creator><creator>Cunha, Rodrigo A.</creator><creator>Fontes Ribeiro, Carlos A.</creator><creator>Köfalvi, Attila</creator><creator>Pereira, Frederico C.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201702</creationdate><title>Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice</title><author>Fonseca, Raquel ; Carvalho, Rui A. ; Lemos, Cristina ; Sequeira, Ana C. ; Pita, Inês R. ; Carvalho, Fábio ; Silva, Carlos D. ; Prediger, Rui D. S. ; Jarak, Ivana ; Cunha, Rodrigo A. ; Fontes Ribeiro, Carlos A. ; Köfalvi, Attila ; Pereira, Frederico C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4769-606f966720632174491009a88454629bb11f2763d0b910d558317109435a8c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anhedonia - drug effects</topic><topic>Animals</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Brain Injuries - chemically induced</topic><topic>Brain Injuries - pathology</topic><topic>Central Nervous System Stimulants - toxicity</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - pathology</topic><topic>Depressive‐like behavior</topic><topic>Disease Models, Animal</topic><topic>Exploratory Behavior - drug effects</topic><topic>Food Preferences - drug effects</topic><topic>Frontal cortex</topic><topic>Glucose - metabolism</topic><topic>Glucose Transporter Type 1 - metabolism</topic><topic>Glucose Transporter Type 3 - metabolism</topic><topic>Glutamic Acid - metabolism</topic><topic>Grooming - drug effects</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Metabolism</topic><topic>Methamphetamine</topic><topic>Methamphetamine - toxicity</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Activity - drug effects</topic><topic>Original</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fonseca, Raquel</creatorcontrib><creatorcontrib>Carvalho, Rui A.</creatorcontrib><creatorcontrib>Lemos, Cristina</creatorcontrib><creatorcontrib>Sequeira, Ana C.</creatorcontrib><creatorcontrib>Pita, Inês R.</creatorcontrib><creatorcontrib>Carvalho, Fábio</creatorcontrib><creatorcontrib>Silva, Carlos D.</creatorcontrib><creatorcontrib>Prediger, Rui D. S.</creatorcontrib><creatorcontrib>Jarak, Ivana</creatorcontrib><creatorcontrib>Cunha, Rodrigo A.</creatorcontrib><creatorcontrib>Fontes Ribeiro, Carlos A.</creatorcontrib><creatorcontrib>Köfalvi, Attila</creatorcontrib><creatorcontrib>Pereira, Frederico C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>CNS neuroscience & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Fonseca, Raquel</au><au>Carvalho, Rui A.</au><au>Lemos, Cristina</au><au>Sequeira, Ana C.</au><au>Pita, Inês R.</au><au>Carvalho, Fábio</au><au>Silva, Carlos D.</au><au>Prediger, Rui D. S.</au><au>Jarak, Ivana</au><au>Cunha, Rodrigo A.</au><au>Fontes Ribeiro, Carlos A.</au><au>Köfalvi, Attila</au><au>Pereira, Frederico C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice</atitle><jtitle>CNS neuroscience & therapeutics</jtitle><addtitle>CNS Neurosci Ther</addtitle><date>2017-02</date><risdate>2017</risdate><volume>23</volume><issue>2</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>1755-5930</issn><eissn>1755-5949</eissn><abstract>Summary
Introduction
We recently showed that a single high dose of methamphetamine (METH) induces a persistent frontal cortical monoamine depletion that is accompanied by helpless‐like behavior in mice. However, brain metabolic alterations underlying both neurochemical and mood alterations remain unknown.
Aims
Herein, we aimed at characterizing frontal cortical metabolic alterations associated with early negative mood behavior triggered by METH. Adult C57BL/6 mice were injected with METH (30 mg/kg, i.p.), and their frontal cortical metabolic status was characterized after probing their mood and anxiety‐related phenotypes 3 days postinjection.
Results
Methamphetamine induced depressive‐like behavior, as indicated by the decreased grooming time in the splash test and by a transient decrease in sucrose preference. At this time, METH did not alter anxiety‐like behavior or motor functions. Depolarization‐induced glucose uptake was reduced in frontocortical slices from METH‐treated mice compared to controls. Consistently, astrocytic glucose transporter (GluT1) density was lower in the METH group. A proton high rotation magic angle spinning (HRMAS) spectroscopic approach revealed that METH induced a significant decrease in N‐acetyl aspartate (NAA) and glutamate levels, suggesting that METH decreased neuronal glutamatergic function in frontal cortex.
Conclusions
We report, for the first time, that a single METH injection triggers early self‐care and hedonic deficits and impairs frontal cortical energetics in mice.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>27762079</pmid><doi>10.1111/cns.12649</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1755-5930 |
| ispartof | CNS neuroscience & therapeutics, 2017-02, Vol.23 (2), p.119-126 |
| issn | 1755-5930 1755-5949 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6492743 |
| source | Wiley Open Access |
| subjects | Anhedonia - drug effects Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Brain Injuries - chemically induced Brain Injuries - pathology Central Nervous System Stimulants - toxicity Cerebral Cortex - drug effects Cerebral Cortex - pathology Depressive‐like behavior Disease Models, Animal Exploratory Behavior - drug effects Food Preferences - drug effects Frontal cortex Glucose - metabolism Glucose Transporter Type 1 - metabolism Glucose Transporter Type 3 - metabolism Glutamic Acid - metabolism Grooming - drug effects Male Maze Learning - drug effects Metabolism Methamphetamine Methamphetamine - toxicity Mice Mice, Inbred C57BL Motor Activity - drug effects Original Rodents |
| title | Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T17%3A12%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methamphetamine%20Induces%20Anhedonic%E2%80%90Like%20Behavior%20and%20Impairs%20Frontal%20Cortical%20Energetics%20in%20Mice&rft.jtitle=CNS%20neuroscience%20&%20therapeutics&rft.au=Fonseca,%20Raquel&rft.date=2017-02&rft.volume=23&rft.issue=2&rft.spage=119&rft.epage=126&rft.pages=119-126&rft.issn=1755-5930&rft.eissn=1755-5949&rft_id=info:doi/10.1111/cns.12649&rft_dat=%3Cproquest_24P%3E4301989981%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1858584054&rft_id=info:pmid/27762079&rfr_iscdi=true |