A new role for RU486 (mifepristone): it protects sperm from premature capacitation during cryopreservation in buffalo

The objective of this study was to determine the mechanism by which RU 486 (mifepristone) protects sperm to undergo premature capacitation during cryopreservation. For this, semen ejaculate (n = 20) was divided into four equal fractions and diluted using egg yolk-based extender supplemented with dif...

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Veröffentlicht in:	Scientific reports 2019-04, Vol.9 (1), p.6712, Article 6712
Hauptverfasser:	Dalal, Jasmer, Kumar, Pradeep, Chandolia, R. K., Pawaria, Shikha, Rajendran, Rasika, Sheoran, Suman, Andonissamy, Jerome, Kumar, Dharmendra
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 14/35 14/63 631/443/494/2732/1577 631/45/776/812 82 82/29 82/83 Animals Antioxidants Antioxidants - pharmacology Buffaloes Calcium Calcium (intracellular) Calcium - metabolism Calcium Channels - metabolism Calcium efflux Calcium influx Calcium Signaling Capacitation Cell Membrane - chemistry Cell Membrane - metabolism Chlortetracycline Cholesterol Cholesterol - metabolism Cryopreservation Cryopreservation - methods Egg Yolk - chemistry Female Fertilization in Vitro Hormone Antagonists - pharmacology Humanities and Social Sciences Intracellular Male Malondialdehyde Mifepristone Mifepristone - pharmacology multidisciplinary Progesterone - metabolism Reactive oxygen species Science Semen Semen - metabolism Semen Preservation - methods Sperm Sperm Capacitation - drug effects Sperm Motility Spermatozoa - cytology Spermatozoa - physiology Tyrosine Yolk Zona pellucida Zygotes
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