Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment

Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducib...

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Veröffentlicht in:	EBioMedicine 2019-04, Vol.42, p.252-269
Hauptverfasser:	Tejero, Rut, Huang, Yong, Katsyv, Igor, Kluge, Michael, Lin, Jung-Yi, Tome-Garcia, Jessica, Daviaud, Nicolas, Wang, Yuanshuo, Zhang, Bin, Tsankova, Nadejda M., Friedel, Caroline C., Zou, Hongyan, Friedel, Roland H.
Format:	Artikel
Sprache:	eng
Schlagworte:	GBM organoid Glioblastoma H2B-GFP Proneural-mesenchymal transition Research paper Stem cell niche Tumor quiescence
Online-Zugang:	Volltext
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