FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy

RAAS inhibition has been the standard treatment for CKD for years because it can reduce proteinuria and hence retard renal function decline, but the proteinuria reduction effect is still insufficient in many patients. Podocyte foot process and slit diaphragm are the final barrier to prevent serum pr...

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Veröffentlicht in:	Scientific reports 2019-04, Vol.9 (1), p.6693-6693, Article 6693
Hauptverfasser:	Li, Szu-Yuan, Chu, Pao-Hsien, Huang, Po-Hsun, Hsieh, Tsung-Han, Susztak, Katalin, Tarng, Der-Cherng
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 13/89 13/95 14/19 14/28 38/77 631/80/128/2031 64/60 692/4022/1585/2759 Angiotensin Angiotensin II Angiotensin II - pharmacology Animal models Animals Case-Control Studies Cell culture Cells, Cultured Clonal deletion Cytology Cytoskeleton Cytoskeleton - metabolism Diaphragm Disease Models, Animal Feet FHL2 protein Focal Adhesion Kinase 1 - metabolism Glomerular Filtration Barrier Humanities and Social Sciences Humans Hypertension Hypertension, Renal - metabolism Hypertension, Renal - pathology Kidney - metabolism Kidney - pathology Kidney diseases LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Male Mice, Inbred C57BL Mice, Knockout multidisciplinary Muscle Proteins - genetics Muscle Proteins - metabolism Nephritis - metabolism Nephritis - pathology Nephropathy Neuropeptides - metabolism Podocytes - pathology Proteinuria Proteinuria - genetics Proteinuria - metabolism rac1 GTP-Binding Protein - metabolism Rac1 protein Renal function Science Science (multidisciplinary) Serum proteins Structure-function relationships Transcription Factors - genetics Transcription Factors - metabolism Urine
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