Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography
In this study, we investigated the relationship between the biomechanical properties of the crystalline lens and intraocular pressure (IOP) using a confocal acoustic radiation force (ARF) and phase-sensitive optical coherence elastography (OCE) system. ARF induced a small displacement at the apex of...
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| Veröffentlicht in: | Biomedical optics express 2018-12, Vol.9 (12), p.6455-6466 |
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| creator | Wu, Chen Aglyamov, Salavat R Han, Zhaolong Singh, Manmohan Liu, Chih-Hao Larin, Kirill V |
| description | In this study, we investigated the relationship between the biomechanical properties of the crystalline lens and intraocular pressure (IOP) using a confocal acoustic radiation force (ARF) and phase-sensitive optical coherence elastography (OCE) system. ARF induced a small displacement at the apex of porcine lenses
at various artificially controlled IOPs. Maximum displacement, relaxation rate, and Young's modulus were utilized to assess the stiffness of the crystalline lens. The results showed that the stiffness of the crystalline increased as IOP increased, but the lens stiffening was not as significant as the stiffening of other ocular tissues such as the cornea and the sclera. A mechanical hysteresis in the lens was also observed while cycling IOP, indicating that the viscoelastic response of the lens is crucial to fully understanding its biomechanical properties. |
| doi_str_mv | 10.1364/BOE.9.006455 |
| format | Article |
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at various artificially controlled IOPs. Maximum displacement, relaxation rate, and Young's modulus were utilized to assess the stiffness of the crystalline lens. The results showed that the stiffness of the crystalline increased as IOP increased, but the lens stiffening was not as significant as the stiffening of other ocular tissues such as the cornea and the sclera. A mechanical hysteresis in the lens was also observed while cycling IOP, indicating that the viscoelastic response of the lens is crucial to fully understanding its biomechanical properties.</description><identifier>ISSN: 2156-7085</identifier><identifier>EISSN: 2156-7085</identifier><identifier>DOI: 10.1364/BOE.9.006455</identifier><identifier>PMID: 31065442</identifier><language>eng</language><publisher>United States: Optical Society of America</publisher><ispartof>Biomedical optics express, 2018-12, Vol.9 (12), p.6455-6466</ispartof><rights>2018 Optical Society of America under the terms of the 2018 Optical Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-4ad9407d4d5e9e3c7c88a70e6d74a66232843ba64ff7d4dae73ebef01ef057fd3</citedby><cites>FETCH-LOGICAL-c427t-4ad9407d4d5e9e3c7c88a70e6d74a66232843ba64ff7d4dae73ebef01ef057fd3</cites><orcidid>0000-0001-8191-9382 ; 0000-0002-8396-5451 ; 0000-0002-5532-5027</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491010/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491010/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31065442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Chen</creatorcontrib><creatorcontrib>Aglyamov, Salavat R</creatorcontrib><creatorcontrib>Han, Zhaolong</creatorcontrib><creatorcontrib>Singh, Manmohan</creatorcontrib><creatorcontrib>Liu, Chih-Hao</creatorcontrib><creatorcontrib>Larin, Kirill V</creatorcontrib><title>Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography</title><title>Biomedical optics express</title><addtitle>Biomed Opt Express</addtitle><description>In this study, we investigated the relationship between the biomechanical properties of the crystalline lens and intraocular pressure (IOP) using a confocal acoustic radiation force (ARF) and phase-sensitive optical coherence elastography (OCE) system. ARF induced a small displacement at the apex of porcine lenses
at various artificially controlled IOPs. Maximum displacement, relaxation rate, and Young's modulus were utilized to assess the stiffness of the crystalline lens. The results showed that the stiffness of the crystalline increased as IOP increased, but the lens stiffening was not as significant as the stiffening of other ocular tissues such as the cornea and the sclera. A mechanical hysteresis in the lens was also observed while cycling IOP, indicating that the viscoelastic response of the lens is crucial to fully understanding its biomechanical properties.</description><issn>2156-7085</issn><issn>2156-7085</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVkc9rFDEUx4MottTePEuOHtw1mWSSmYtQS_0BhV70HN5m3uxEssmYZJT9L_yTzXRrqSEhD96Hz3vwJeQ1Z1sulHz_8e5m228ZU7Jtn5Hzhrdqo1nXPn9Sn5HLnH-weqTUTHQvyZngTLVSNufkz1XOmLMLe1ompDsXD2gnCM6Cp3OKM6biMNM43vfnmKwLSG065gLer7XHkCnUS8cl2OJiWGkXSoJoFw-peuqIJSH97cpE41zu7TZOmDBYpOghl7hPME_HV-TFCD7j5cN_Qb5_uvl2_WVze_f56_XV7cbKRpeNhKGXTA9yaLFHYbXtOtAM1aAlKNWIppNiB0qO4woBaoE7HBmvr9XjIC7Ih5N3XnYHHCyu-3ozJ3eAdDQRnPm_E9xk9vGXUbLnjLMqePsgSPHngrmYg8sWvYeAccmmaQTvei60qui7E2pTzDnh-DiGM7PmaGqOpjenHCv-5ulqj_C_1MRfi1eeEA</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Wu, Chen</creator><creator>Aglyamov, Salavat R</creator><creator>Han, Zhaolong</creator><creator>Singh, Manmohan</creator><creator>Liu, Chih-Hao</creator><creator>Larin, Kirill V</creator><general>Optical Society of America</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8191-9382</orcidid><orcidid>https://orcid.org/0000-0002-8396-5451</orcidid><orcidid>https://orcid.org/0000-0002-5532-5027</orcidid></search><sort><creationdate>20181201</creationdate><title>Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography</title><author>Wu, Chen ; Aglyamov, Salavat R ; Han, Zhaolong ; Singh, Manmohan ; Liu, Chih-Hao ; Larin, Kirill V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-4ad9407d4d5e9e3c7c88a70e6d74a66232843ba64ff7d4dae73ebef01ef057fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Chen</creatorcontrib><creatorcontrib>Aglyamov, Salavat R</creatorcontrib><creatorcontrib>Han, Zhaolong</creatorcontrib><creatorcontrib>Singh, Manmohan</creatorcontrib><creatorcontrib>Liu, Chih-Hao</creatorcontrib><creatorcontrib>Larin, Kirill V</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical optics express</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Chen</au><au>Aglyamov, Salavat R</au><au>Han, Zhaolong</au><au>Singh, Manmohan</au><au>Liu, Chih-Hao</au><au>Larin, Kirill V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography</atitle><jtitle>Biomedical optics express</jtitle><addtitle>Biomed Opt Express</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>9</volume><issue>12</issue><spage>6455</spage><epage>6466</epage><pages>6455-6466</pages><issn>2156-7085</issn><eissn>2156-7085</eissn><abstract>In this study, we investigated the relationship between the biomechanical properties of the crystalline lens and intraocular pressure (IOP) using a confocal acoustic radiation force (ARF) and phase-sensitive optical coherence elastography (OCE) system. ARF induced a small displacement at the apex of porcine lenses
at various artificially controlled IOPs. Maximum displacement, relaxation rate, and Young's modulus were utilized to assess the stiffness of the crystalline lens. The results showed that the stiffness of the crystalline increased as IOP increased, but the lens stiffening was not as significant as the stiffening of other ocular tissues such as the cornea and the sclera. A mechanical hysteresis in the lens was also observed while cycling IOP, indicating that the viscoelastic response of the lens is crucial to fully understanding its biomechanical properties.</abstract><cop>United States</cop><pub>Optical Society of America</pub><pmid>31065442</pmid><doi>10.1364/BOE.9.006455</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8191-9382</orcidid><orcidid>https://orcid.org/0000-0002-8396-5451</orcidid><orcidid>https://orcid.org/0000-0002-5532-5027</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography |
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