Nuclear and membrane estrogen receptor antagonists induce similar mTORC2 activation‐reversible changes in synaptic protein expression and actin polymerization in the mouse hippocampus

Summary Aims Estrogens play pivotal roles in hippocampal synaptic plasticity through nuclear receptors (nERs; including ERα and ERβ) and the membrane receptor (mER; also called GPR30), but the underlying mechanism and the contributions of nERs and mER remain unclear. Mammalian target of rapamycin co...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2018-06, Vol.24 (6), p.495-507
Hauptverfasser:	Xing, Fang‐Zhou, Zhao, Yan‐Gang, Zhang, Yuan‐Yuan, He, Li, Zhao, Ji‐Kai, Liu, Meng‐Ying, Liu, Yan, Zhang, Ji‐Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin actin polymerization Actins - metabolism Alzheimer's disease Animals Benzodioxoles - pharmacology Cofilin Cytoskeleton Dementia disorders Enzyme Inhibitors - pharmacology Estrogen Receptor Antagonists - pharmacology Estrogen receptors Female Glutamic acid receptors (ionotropic) Hippocampal plasticity Hippocampus Hippocampus - drug effects Indazoles - pharmacology Indoles - pharmacology Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors Mechanistic Target of Rapamycin Complex 2 - metabolism Mice Mice, Inbred C57BL Microscopy, Electron, Transmission mTORC2 Nerve Tissue Proteins - metabolism Neurodegenerative diseases Nuclear Receptor Coactivator 1 - metabolism Nuclear receptors Original Polymerization Polymerization - drug effects Postsynaptic density proteins Profilin Protein expression Pyrazoles - pharmacology Pyrimidines - pharmacology Quinolines - pharmacology Rapamycin Signal Transduction - drug effects Silver Staining Spinophilin Src protein Synapses Synapses - metabolism Synapses - ultrastructure Synaptic density Synaptic plasticity Synaptophysin TOR protein
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