Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells

Epigenetic modifications are closely related to oncogene activation and tumor suppressor gene inactivation. The aim of this study was to determine the effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Cell proliferation, metastasis, invasion and apoptosis were respective...

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Veröffentlicht in:	Oncology reports 2019-06, Vol.41 (6), p.3209-3218
Hauptverfasser:	Zhao, Lingqin, Shou, Huafeng, Chen, Lu, Gao, Wen, Fang, Chenyan, Zhang, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Cancer cells Cancer metastasis Cancer therapies Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cyclin-Dependent Kinase Inhibitor p16 - genetics Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 - genetics DNA (Cytosine-5-)-Methyltransferases - genetics DNA methylation DNA Methylation - genetics DNA Methyltransferase 3A DNA Methyltransferase 3B Dosage and administration Epigenesis, Genetic Epigenetic inheritance Epigenetics Female Gene Expression Regulation, Neoplastic - drug effects Genes Genetic aspects Ginsenosides - pharmacology Health aspects Humans Medical prognosis Messenger RNA Metastasis Methylation Methyltransferases Mortality MutL Protein Homolog 1 - genetics Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Physiological aspects Polymerase chain reaction Post-translational modifications RNA Saponins Signal Transduction - drug effects Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumors Wound care Wound healing
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