Androgen receptor dampens tissue factor expression via nuclear factor‐κB and early growth response protein 1

Essentials Androgen deprivation increases the rate of venous thromboembolism in prostate cancer patients. We characterized androgen receptor‐mediated tissue factor regulation in prostate epithelial cells. Androgen receptor is dampening tissue factor expression in prostate epithelial cells. Androgen...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2018-04, Vol.16 (4), p.749-758
Hauptverfasser:	Hoesel, B., Mussbacher, M., Dikorman, B., Salzmann, M., Assinger, A., Hell, L., Thaler, J., Basílio, J., Moser, B., Resch, U., Paar, H., Mackman, N., Schmid, J. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - adverse effects androgen receptor Androgen receptors Androgens Androgens - pharmacology Animals Binding Sites Castration Cell Line, Tumor COAGULATION Dihydrotestosterone - pharmacology Down-Regulation early growth response protein 1 Early Growth Response Protein 1 - metabolism EGR-1 protein Epithelial cells Epithelial Cells - metabolism Gene expression Humans Male Mice, Inbred C57BL Myc protein NF-kappa B - metabolism NF‐κB Orchiectomy Original Promoter Regions, Genetic Prostate - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Protein Binding Proteins Receptors, Androgen - drug effects Receptors, Androgen - metabolism Signal Transduction Testosterone Thromboembolism Thromboplastin - genetics Thromboplastin - metabolism Tissue factor Tumor cell lines venous thromboembolism Venous Thromboembolism - chemically induced Venous Thromboembolism - genetics Venous Thromboembolism - metabolism
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