Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan
Aims There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ve...
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| Veröffentlicht in: | ESC Heart Failure 2019-06, Vol.6 (3), p.475-486 |
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| creator | Shiga, Tsuyoshi Suzuki, Atsushi Haruta, Shoji Mori, Fumiaki Ota, Yoshimi Yagi, Masahiro Oka, Toshiaki Tanaka, Hiroyuki Murasaki, Satoshi Yamauchi, Takao Katoh, Joji Hattori, Hidetoshi Kikuchi, Noriko Watanabe, Erisa Yamada, Yuichiro Haruki, Shintaro Kogure, Tomohito Suzuki, Tsuyoshi Uetsuka, Yoshio Hagiwara, Nobuhisa |
| description | Aims
There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ventricular ejection fraction (LVEF) stratum.
Methods and results
We retrospectively conducted a multicentre cohort study of 1245 hospitalized patients with decompensated HF between 2013 and 2014. Of these patients, 36% had an LVEF 7 days for >90% of patients. In‐hospital mortality was 7%, but was not different among the LVEF groups (HFrEF 7%, HFmrEF 6%, and HFpEF 8%). After a median follow‐up of 19 months (range, 3–26 months), 192 (17%) of the 1156 patients who were discharged alive died, and 534 (46%) were re‐hospitalized after hospital discharge. There were no significant differences in mortality after hospital discharge among the three LVEF groups (HFrEF 18%, HFmrEF 16%, and HFpEF 16%). There were no differences in cardiac death or re‐hospitalization due to worsened HF after hospital discharge among the LVEF groups (cardiac death: HFrEF 8%, HFmrEF 7%, and HFpEF 7%; re‐hospitalization due to worsened HF: HFrEF 19%, HFmrEF 16%, and HFpEF 17%). Multivariable‐adjusted analyses showed that the HFmrEF and HFrEF groups, compared with the HFpEF group, were not associated with an increased risk for in‐hospital death or death after hospital discharge. Non‐cardiac causes of death and re‐hospitalization after hospital discharge accounted for 35% and 38%, respectively.
Conclusions
Our results revealed different clinical characteristics but similar mortality rates in the HFrEF, HFmrEF, |
| doi_str_mv | 10.1002/ehf2.12418 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6487690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2247632896</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4768-682991aafed68e49cbeb25eb3cfa47f2260a7d262b91a80185a5ac31d8653c2d3</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhiMEolXphQdAlrgg1C32JHacC1K1aimoEhc4W7P2pPEq6wQ7aVVOHHiAPmOfBC9bqsKBk0fyN__8v_6ieCn4seAc3lHXwrGASugnxT5wKRdSAzx9NO8VhymtOedCKiGhel7slVxDk7f3i5_L3gdvsWe2w4h2oujT5G1iQ8u6IY1-wt5_J8c6wjixFn0_R2IjTp7ClNi1nzo2RkoUr8gdsY13dz9uI4ZLOmIYHIvkZpv3aU128kNg7fZMHhLzgX3CEcOL4lmLfaLD-_eg-Hp2-mV5vrj4_OHj8uRiYata6YXKphuB2JJTmqrGrmgFklalbbGqWwDFsXagYJUpzYWWKNGWwmklSwuuPCje73THebUhZ3OAiL0Zo99gvDEDevP3T_CduRyujKp0rRqeBd7cC8Th20xpMhufLPU9BhrmZEDoupFSlmVGX_-Droc5hhzPAOQ4JehGZertjrJxSClS-2BGcLPt12z7Nb_7zfCrx_Yf0D9tZkDsgGvf081_pMzp-RnsRH8BCiCzKg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2247632896</pqid></control><display><type>article</type><title>Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Shiga, Tsuyoshi ; Suzuki, Atsushi ; Haruta, Shoji ; Mori, Fumiaki ; Ota, Yoshimi ; Yagi, Masahiro ; Oka, Toshiaki ; Tanaka, Hiroyuki ; Murasaki, Satoshi ; Yamauchi, Takao ; Katoh, Joji ; Hattori, Hidetoshi ; Kikuchi, Noriko ; Watanabe, Erisa ; Yamada, Yuichiro ; Haruki, Shintaro ; Kogure, Tomohito ; Suzuki, Tsuyoshi ; Uetsuka, Yoshio ; Hagiwara, Nobuhisa</creator><creatorcontrib>Shiga, Tsuyoshi ; Suzuki, Atsushi ; Haruta, Shoji ; Mori, Fumiaki ; Ota, Yoshimi ; Yagi, Masahiro ; Oka, Toshiaki ; Tanaka, Hiroyuki ; Murasaki, Satoshi ; Yamauchi, Takao ; Katoh, Joji ; Hattori, Hidetoshi ; Kikuchi, Noriko ; Watanabe, Erisa ; Yamada, Yuichiro ; Haruki, Shintaro ; Kogure, Tomohito ; Suzuki, Tsuyoshi ; Uetsuka, Yoshio ; Hagiwara, Nobuhisa ; HIJ-HF II Investigators ; the HIJ‐HF II Investigators</creatorcontrib><description>Aims
There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ventricular ejection fraction (LVEF) stratum.
Methods and results
We retrospectively conducted a multicentre cohort study of 1245 hospitalized patients with decompensated HF between 2013 and 2014. Of these patients, 36% had an LVEF < 40% [HF with reduced ejection fraction (HFrEF), median age 72 years, 71% male], 21% had an LVEF 40–49% [HF with mid‐range EF (HFmrEF), 77 years, 56% male], and 43% had an LVEF ≥ 50% [HF with preserved EF (HFpEF), 81 years, 44% male]. The primary outcome was death from any cause, and the secondary outcomes were cardiac death and re‐hospitalization due to worsened HF after hospital discharge. There were high proportions of non‐ischaemic cardiomyopathy (32%) in HFrEF patients, coronary artery disease (44%) in HFmrEF patients, and valvular disease (39%) in HFpEF patients. The frequencies of intravenous diuretic and natriuretic peptide administration during hospitalization were 66% and 30%, respectively. The median hospital stay for the overall population was 19 days, and the length of stay was >7 days for >90% of patients. In‐hospital mortality was 7%, but was not different among the LVEF groups (HFrEF 7%, HFmrEF 6%, and HFpEF 8%). After a median follow‐up of 19 months (range, 3–26 months), 192 (17%) of the 1156 patients who were discharged alive died, and 534 (46%) were re‐hospitalized after hospital discharge. There were no significant differences in mortality after hospital discharge among the three LVEF groups (HFrEF 18%, HFmrEF 16%, and HFpEF 16%). There were no differences in cardiac death or re‐hospitalization due to worsened HF after hospital discharge among the LVEF groups (cardiac death: HFrEF 8%, HFmrEF 7%, and HFpEF 7%; re‐hospitalization due to worsened HF: HFrEF 19%, HFmrEF 16%, and HFpEF 17%). Multivariable‐adjusted analyses showed that the HFmrEF and HFrEF groups, compared with the HFpEF group, were not associated with an increased risk for in‐hospital death or death after hospital discharge. Non‐cardiac causes of death and re‐hospitalization after hospital discharge accounted for 35% and 38%, respectively.
Conclusions
Our results revealed different clinical characteristics but similar mortality rates in the HFrEF, HFmrEF, and HFpEF groups. The most common cause of death and re‐hospitalization after hospital discharge was HF, but non‐cardiac causes also contributed to their prognosis. Integrated management approaches will be required for HF patients.</description><identifier>ISSN: 2055-5822</identifier><identifier>EISSN: 2055-5822</identifier><identifier>DOI: 10.1002/ehf2.12418</identifier><identifier>PMID: 30829002</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Aged ; Aged, 80 and over ; Blood pressure ; Cardiovascular disease ; Congenital diseases ; Coronary vessels ; Dyspnea ; Edema ; Ejection fraction ; Female ; Heart attacks ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - epidemiology ; Heart Failure - mortality ; Heart Failure - physiopathology ; Hospitalization ; Hospitalization - statistics & numerical data ; Hospitals ; Humans ; Hypertension ; Japan - epidemiology ; Japanese ; Left ventricular ejection fraction ; Male ; Medical imaging ; Middle Aged ; Mortality ; Original ; Original s ; Patients ; Prognosis ; R&D ; Research & development ; Retrospective Studies ; Stroke Volume - physiology ; Studies ; Womens health</subject><ispartof>ESC Heart Failure, 2019-06, Vol.6 (3), p.475-486</ispartof><rights>2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4768-682991aafed68e49cbeb25eb3cfa47f2260a7d262b91a80185a5ac31d8653c2d3</citedby><cites>FETCH-LOGICAL-c4768-682991aafed68e49cbeb25eb3cfa47f2260a7d262b91a80185a5ac31d8653c2d3</cites><orcidid>0000-0003-0358-7196</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487690/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487690/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30829002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiga, Tsuyoshi</creatorcontrib><creatorcontrib>Suzuki, Atsushi</creatorcontrib><creatorcontrib>Haruta, Shoji</creatorcontrib><creatorcontrib>Mori, Fumiaki</creatorcontrib><creatorcontrib>Ota, Yoshimi</creatorcontrib><creatorcontrib>Yagi, Masahiro</creatorcontrib><creatorcontrib>Oka, Toshiaki</creatorcontrib><creatorcontrib>Tanaka, Hiroyuki</creatorcontrib><creatorcontrib>Murasaki, Satoshi</creatorcontrib><creatorcontrib>Yamauchi, Takao</creatorcontrib><creatorcontrib>Katoh, Joji</creatorcontrib><creatorcontrib>Hattori, Hidetoshi</creatorcontrib><creatorcontrib>Kikuchi, Noriko</creatorcontrib><creatorcontrib>Watanabe, Erisa</creatorcontrib><creatorcontrib>Yamada, Yuichiro</creatorcontrib><creatorcontrib>Haruki, Shintaro</creatorcontrib><creatorcontrib>Kogure, Tomohito</creatorcontrib><creatorcontrib>Suzuki, Tsuyoshi</creatorcontrib><creatorcontrib>Uetsuka, Yoshio</creatorcontrib><creatorcontrib>Hagiwara, Nobuhisa</creatorcontrib><creatorcontrib>HIJ-HF II Investigators</creatorcontrib><creatorcontrib>the HIJ‐HF II Investigators</creatorcontrib><title>Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan</title><title>ESC Heart Failure</title><addtitle>ESC Heart Fail</addtitle><description>Aims
There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ventricular ejection fraction (LVEF) stratum.
Methods and results
We retrospectively conducted a multicentre cohort study of 1245 hospitalized patients with decompensated HF between 2013 and 2014. Of these patients, 36% had an LVEF < 40% [HF with reduced ejection fraction (HFrEF), median age 72 years, 71% male], 21% had an LVEF 40–49% [HF with mid‐range EF (HFmrEF), 77 years, 56% male], and 43% had an LVEF ≥ 50% [HF with preserved EF (HFpEF), 81 years, 44% male]. The primary outcome was death from any cause, and the secondary outcomes were cardiac death and re‐hospitalization due to worsened HF after hospital discharge. There were high proportions of non‐ischaemic cardiomyopathy (32%) in HFrEF patients, coronary artery disease (44%) in HFmrEF patients, and valvular disease (39%) in HFpEF patients. The frequencies of intravenous diuretic and natriuretic peptide administration during hospitalization were 66% and 30%, respectively. The median hospital stay for the overall population was 19 days, and the length of stay was >7 days for >90% of patients. In‐hospital mortality was 7%, but was not different among the LVEF groups (HFrEF 7%, HFmrEF 6%, and HFpEF 8%). After a median follow‐up of 19 months (range, 3–26 months), 192 (17%) of the 1156 patients who were discharged alive died, and 534 (46%) were re‐hospitalized after hospital discharge. There were no significant differences in mortality after hospital discharge among the three LVEF groups (HFrEF 18%, HFmrEF 16%, and HFpEF 16%). There were no differences in cardiac death or re‐hospitalization due to worsened HF after hospital discharge among the LVEF groups (cardiac death: HFrEF 8%, HFmrEF 7%, and HFpEF 7%; re‐hospitalization due to worsened HF: HFrEF 19%, HFmrEF 16%, and HFpEF 17%). Multivariable‐adjusted analyses showed that the HFmrEF and HFrEF groups, compared with the HFpEF group, were not associated with an increased risk for in‐hospital death or death after hospital discharge. Non‐cardiac causes of death and re‐hospitalization after hospital discharge accounted for 35% and 38%, respectively.
Conclusions
Our results revealed different clinical characteristics but similar mortality rates in the HFrEF, HFmrEF, and HFpEF groups. The most common cause of death and re‐hospitalization after hospital discharge was HF, but non‐cardiac causes also contributed to their prognosis. Integrated management approaches will be required for HF patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Congenital diseases</subject><subject>Coronary vessels</subject><subject>Dyspnea</subject><subject>Edema</subject><subject>Ejection fraction</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - mortality</subject><subject>Heart Failure - physiopathology</subject><subject>Hospitalization</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Japan - epidemiology</subject><subject>Japanese</subject><subject>Left ventricular ejection fraction</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original</subject><subject>Original s</subject><subject>Patients</subject><subject>Prognosis</subject><subject>R&D</subject><subject>Research & development</subject><subject>Retrospective Studies</subject><subject>Stroke Volume - physiology</subject><subject>Studies</subject><subject>Womens health</subject><issn>2055-5822</issn><issn>2055-5822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kcFu1DAQhiMEolXphQdAlrgg1C32JHacC1K1aimoEhc4W7P2pPEq6wQ7aVVOHHiAPmOfBC9bqsKBk0fyN__8v_6ieCn4seAc3lHXwrGASugnxT5wKRdSAzx9NO8VhymtOedCKiGhel7slVxDk7f3i5_L3gdvsWe2w4h2oujT5G1iQ8u6IY1-wt5_J8c6wjixFn0_R2IjTp7ClNi1nzo2RkoUr8gdsY13dz9uI4ZLOmIYHIvkZpv3aU128kNg7fZMHhLzgX3CEcOL4lmLfaLD-_eg-Hp2-mV5vrj4_OHj8uRiYata6YXKphuB2JJTmqrGrmgFklalbbGqWwDFsXagYJUpzYWWKNGWwmklSwuuPCje73THebUhZ3OAiL0Zo99gvDEDevP3T_CduRyujKp0rRqeBd7cC8Th20xpMhufLPU9BhrmZEDoupFSlmVGX_-Droc5hhzPAOQ4JehGZertjrJxSClS-2BGcLPt12z7Nb_7zfCrx_Yf0D9tZkDsgGvf081_pMzp-RnsRH8BCiCzKg</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Shiga, Tsuyoshi</creator><creator>Suzuki, Atsushi</creator><creator>Haruta, Shoji</creator><creator>Mori, Fumiaki</creator><creator>Ota, Yoshimi</creator><creator>Yagi, Masahiro</creator><creator>Oka, Toshiaki</creator><creator>Tanaka, Hiroyuki</creator><creator>Murasaki, Satoshi</creator><creator>Yamauchi, Takao</creator><creator>Katoh, Joji</creator><creator>Hattori, Hidetoshi</creator><creator>Kikuchi, Noriko</creator><creator>Watanabe, Erisa</creator><creator>Yamada, Yuichiro</creator><creator>Haruki, Shintaro</creator><creator>Kogure, Tomohito</creator><creator>Suzuki, Tsuyoshi</creator><creator>Uetsuka, Yoshio</creator><creator>Hagiwara, Nobuhisa</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0358-7196</orcidid></search><sort><creationdate>201906</creationdate><title>Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan</title><author>Shiga, Tsuyoshi ; Suzuki, Atsushi ; Haruta, Shoji ; Mori, Fumiaki ; Ota, Yoshimi ; Yagi, Masahiro ; Oka, Toshiaki ; Tanaka, Hiroyuki ; Murasaki, Satoshi ; Yamauchi, Takao ; Katoh, Joji ; Hattori, Hidetoshi ; Kikuchi, Noriko ; Watanabe, Erisa ; Yamada, Yuichiro ; Haruki, Shintaro ; Kogure, Tomohito ; Suzuki, Tsuyoshi ; Uetsuka, Yoshio ; Hagiwara, Nobuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4768-682991aafed68e49cbeb25eb3cfa47f2260a7d262b91a80185a5ac31d8653c2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Congenital diseases</topic><topic>Coronary vessels</topic><topic>Dyspnea</topic><topic>Edema</topic><topic>Ejection fraction</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - mortality</topic><topic>Heart Failure - physiopathology</topic><topic>Hospitalization</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Japan - epidemiology</topic><topic>Japanese</topic><topic>Left ventricular ejection fraction</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Original</topic><topic>Original s</topic><topic>Patients</topic><topic>Prognosis</topic><topic>R&D</topic><topic>Research & development</topic><topic>Retrospective Studies</topic><topic>Stroke Volume - physiology</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiga, Tsuyoshi</creatorcontrib><creatorcontrib>Suzuki, Atsushi</creatorcontrib><creatorcontrib>Haruta, Shoji</creatorcontrib><creatorcontrib>Mori, Fumiaki</creatorcontrib><creatorcontrib>Ota, Yoshimi</creatorcontrib><creatorcontrib>Yagi, Masahiro</creatorcontrib><creatorcontrib>Oka, Toshiaki</creatorcontrib><creatorcontrib>Tanaka, Hiroyuki</creatorcontrib><creatorcontrib>Murasaki, Satoshi</creatorcontrib><creatorcontrib>Yamauchi, Takao</creatorcontrib><creatorcontrib>Katoh, Joji</creatorcontrib><creatorcontrib>Hattori, Hidetoshi</creatorcontrib><creatorcontrib>Kikuchi, Noriko</creatorcontrib><creatorcontrib>Watanabe, Erisa</creatorcontrib><creatorcontrib>Yamada, Yuichiro</creatorcontrib><creatorcontrib>Haruki, Shintaro</creatorcontrib><creatorcontrib>Kogure, Tomohito</creatorcontrib><creatorcontrib>Suzuki, Tsuyoshi</creatorcontrib><creatorcontrib>Uetsuka, Yoshio</creatorcontrib><creatorcontrib>Hagiwara, Nobuhisa</creatorcontrib><creatorcontrib>HIJ-HF II Investigators</creatorcontrib><creatorcontrib>the HIJ‐HF II Investigators</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ESC Heart Failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiga, Tsuyoshi</au><au>Suzuki, Atsushi</au><au>Haruta, Shoji</au><au>Mori, Fumiaki</au><au>Ota, Yoshimi</au><au>Yagi, Masahiro</au><au>Oka, Toshiaki</au><au>Tanaka, Hiroyuki</au><au>Murasaki, Satoshi</au><au>Yamauchi, Takao</au><au>Katoh, Joji</au><au>Hattori, Hidetoshi</au><au>Kikuchi, Noriko</au><au>Watanabe, Erisa</au><au>Yamada, Yuichiro</au><au>Haruki, Shintaro</au><au>Kogure, Tomohito</au><au>Suzuki, Tsuyoshi</au><au>Uetsuka, Yoshio</au><au>Hagiwara, Nobuhisa</au><aucorp>HIJ-HF II Investigators</aucorp><aucorp>the HIJ‐HF II Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan</atitle><jtitle>ESC Heart Failure</jtitle><addtitle>ESC Heart Fail</addtitle><date>2019-06</date><risdate>2019</risdate><volume>6</volume><issue>3</issue><spage>475</spage><epage>486</epage><pages>475-486</pages><issn>2055-5822</issn><eissn>2055-5822</eissn><abstract>Aims
There are regional differences in the patient characteristics, management, and outcomes of hospitalized patients with heart failure (HF). The aim of this study was to evaluate the clinical characteristics and outcomes of Japanese patients who are hospitalized with HF on the basis of the left ventricular ejection fraction (LVEF) stratum.
Methods and results
We retrospectively conducted a multicentre cohort study of 1245 hospitalized patients with decompensated HF between 2013 and 2014. Of these patients, 36% had an LVEF < 40% [HF with reduced ejection fraction (HFrEF), median age 72 years, 71% male], 21% had an LVEF 40–49% [HF with mid‐range EF (HFmrEF), 77 years, 56% male], and 43% had an LVEF ≥ 50% [HF with preserved EF (HFpEF), 81 years, 44% male]. The primary outcome was death from any cause, and the secondary outcomes were cardiac death and re‐hospitalization due to worsened HF after hospital discharge. There were high proportions of non‐ischaemic cardiomyopathy (32%) in HFrEF patients, coronary artery disease (44%) in HFmrEF patients, and valvular disease (39%) in HFpEF patients. The frequencies of intravenous diuretic and natriuretic peptide administration during hospitalization were 66% and 30%, respectively. The median hospital stay for the overall population was 19 days, and the length of stay was >7 days for >90% of patients. In‐hospital mortality was 7%, but was not different among the LVEF groups (HFrEF 7%, HFmrEF 6%, and HFpEF 8%). After a median follow‐up of 19 months (range, 3–26 months), 192 (17%) of the 1156 patients who were discharged alive died, and 534 (46%) were re‐hospitalized after hospital discharge. There were no significant differences in mortality after hospital discharge among the three LVEF groups (HFrEF 18%, HFmrEF 16%, and HFpEF 16%). There were no differences in cardiac death or re‐hospitalization due to worsened HF after hospital discharge among the LVEF groups (cardiac death: HFrEF 8%, HFmrEF 7%, and HFpEF 7%; re‐hospitalization due to worsened HF: HFrEF 19%, HFmrEF 16%, and HFpEF 17%). Multivariable‐adjusted analyses showed that the HFmrEF and HFrEF groups, compared with the HFpEF group, were not associated with an increased risk for in‐hospital death or death after hospital discharge. Non‐cardiac causes of death and re‐hospitalization after hospital discharge accounted for 35% and 38%, respectively.
Conclusions
Our results revealed different clinical characteristics but similar mortality rates in the HFrEF, HFmrEF, and HFpEF groups. The most common cause of death and re‐hospitalization after hospital discharge was HF, but non‐cardiac causes also contributed to their prognosis. Integrated management approaches will be required for HF patients.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>30829002</pmid><doi>10.1002/ehf2.12418</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0358-7196</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2055-5822 |
| ispartof | ESC Heart Failure, 2019-06, Vol.6 (3), p.475-486 |
| issn | 2055-5822 2055-5822 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6487690 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Aged Aged, 80 and over Blood pressure Cardiovascular disease Congenital diseases Coronary vessels Dyspnea Edema Ejection fraction Female Heart attacks Heart failure Heart Failure - diagnosis Heart Failure - epidemiology Heart Failure - mortality Heart Failure - physiopathology Hospitalization Hospitalization - statistics & numerical data Hospitals Humans Hypertension Japan - epidemiology Japanese Left ventricular ejection fraction Male Medical imaging Middle Aged Mortality Original Original s Patients Prognosis R&D Research & development Retrospective Studies Stroke Volume - physiology Studies Womens health |
| title | Clinical characteristics of hospitalized heart failure patients with preserved, mid‐range, and reduced ejection fractions in Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T05%3A52%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20characteristics%20of%20hospitalized%20heart%20failure%20patients%20with%20preserved,%20mid%E2%80%90range,%20and%20reduced%20ejection%20fractions%20in%20Japan&rft.jtitle=ESC%20Heart%20Failure&rft.au=Shiga,%20Tsuyoshi&rft.aucorp=HIJ-HF%20II%20Investigators&rft.date=2019-06&rft.volume=6&rft.issue=3&rft.spage=475&rft.epage=486&rft.pages=475-486&rft.issn=2055-5822&rft.eissn=2055-5822&rft_id=info:doi/10.1002/ehf2.12418&rft_dat=%3Cproquest_pubme%3E2247632896%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2247632896&rft_id=info:pmid/30829002&rfr_iscdi=true |