Single and combined effects of plant‐derived and synthetic cannabinoids on cognition and cannabinoid‐associated withdrawal signs in mice

Background and Purpose It has been suggested that the non‐euphorogenic phytocannabinoid cannabidiol (CBD) can ameliorate adverse effects of Δ9‐tetrahydrocannabinol (THC). We determined whether CBD ameliorates cognitive deficits and withdrawal signs induced by cannabinoid CB1/CB2 receptor agonists or...

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Veröffentlicht in:	British journal of pharmacology 2019-05, Vol.176 (10), p.1552-1567
Hauptverfasser:	Myers, Alyssa M, Siegele, Patrick B, Foss, Jeffrey D, Tuma, Ronald F, Ward, Sara Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Antagonists Anxiety Cannabidiol - administration & dosage Cannabidiol - isolation & purification Cannabidiol - pharmacology Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoid Receptor Agonists - administration & dosage Cannabinoid Receptor Agonists - adverse effects Cannabinoid Receptor Agonists - chemical synthesis Cannabinoid Receptor Antagonists - pharmacology Cannabinoids Cannabis - chemistry Capsaicin receptors Capsazepine Cognition - drug effects Cognitive ability Cognitive tasks Dronabinol - administration & dosage Dronabinol - adverse effects Dronabinol - chemical synthesis Mice Mice, Inbred C57BL Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - agonists Research Paper Substance Withdrawal Syndrome - etiology Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - prevention & control Tetrahydrocannabinol Themed Section: Research Papers
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