Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study
is one of the most common causes of keratitis. The current study was done to evaluate the therapeutic effects of antibacterial combinations with Silver nanoparticles (Ag-NPs) and Ciprofloxacin in experimental keratitis. Sixty four New Zealand rabbits were prepared. All rabbits were randomly categori...
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| Veröffentlicht in: | Iranian journal of pharmaceutical research : IJPR 2019-01, Vol.18 (1), p.320-327 |
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| container_title | Iranian journal of pharmaceutical research : IJPR |
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| creator | Zavarshani, Mohammad Ahmadi, Malahat Dastmalchi Saei, Habib Tehrani, Ali Asghar Dalir Naghadeh, Bahram |
| description | is one of the most common causes of keratitis. The current study was done to evaluate the therapeutic effects of antibacterial combinations with Silver nanoparticles (Ag-NPs) and Ciprofloxacin in experimental
keratitis. Sixty four New Zealand rabbits were prepared. All rabbits were randomly categorized into eight groups (each group containing eight rabbits): Control +, Control -, Ciprofloxacin, Ag-NPs, Ciprofloxacin plus Betamethasone, Ag-NPs plus Betamethasone, Ciprofloxacin plus Ag-NPs, and Ciprofloxacin plus Ag-NPs plus Betamethasone. Twelve hours after bacterial inoculation into the cornea, the eyes were examined daily to evaluate the number of days of ocular discharge and blepharospasm. Also, after 108 and 204 h, first grading of corneal opacity was done and then four rabbits of each groups were euthanized for bacterial count. The results showed that the means of days of blepharospasm, ocular discharge, and bacterial counts (log CFU mL
) were significantly different in the treatment groups at 108 and 204 h ( |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6487424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2232008627</sourcerecordid><originalsourceid>FETCH-LOGICAL-p196t-9163f284d155398d7aaab529ddf200e44ee18cbe0175cd78606682297c72382b3</originalsourceid><addsrcrecordid>eNpVkUFr3DAQhU1JaLbb_oWiYw4xyJItyzkEwrJtCksSutuzGVvjrhJbciU5ZP9Qfmdkug3NaQbmve89mA_JIiuZSIWs6Mm88yKlnMmz5JP3D5QWosrpx-SMZ1RWXIhF8rKywwhOe2vIbo8ORpyCbsm667ANntiOrPTobNfbZ2i1uSBb3T-hI7dgbDRGbY-egFGzXTsSeY02EHQEakPCHsnOIYQBTZhp9x4nZQdrwJPHmBd00H5W_oSm0eGSXBuyfh7R6dkBPdmGSR0-J6cd9B6_HOcy-fVtvVvdpJu77z9W15t0zCoR0ioTvGMyV1lR8EqqEgCaglVKdYxSzHPETLYN0qwsWlVKQYWQjFVlWzIuWcOXydVf7jg1A6o2VnDQ12NsA-5QW9D1-4vR-_q3fapFLsuc5RFwfgQ4-2dCH-pB-xb7HgzaydeM8dhEClZG6df_s95C_j2HvwJOdJB6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232008627</pqid></control><display><type>article</type><title>Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Zavarshani, Mohammad ; Ahmadi, Malahat ; Dastmalchi Saei, Habib ; Tehrani, Ali Asghar ; Dalir Naghadeh, Bahram</creator><creatorcontrib>Zavarshani, Mohammad ; Ahmadi, Malahat ; Dastmalchi Saei, Habib ; Tehrani, Ali Asghar ; Dalir Naghadeh, Bahram</creatorcontrib><description>is one of the most common causes of keratitis. The current study was done to evaluate the therapeutic effects of antibacterial combinations with Silver nanoparticles (Ag-NPs) and Ciprofloxacin in experimental
keratitis. Sixty four New Zealand rabbits were prepared. All rabbits were randomly categorized into eight groups (each group containing eight rabbits): Control +, Control -, Ciprofloxacin, Ag-NPs, Ciprofloxacin plus Betamethasone, Ag-NPs plus Betamethasone, Ciprofloxacin plus Ag-NPs, and Ciprofloxacin plus Ag-NPs plus Betamethasone. Twelve hours after bacterial inoculation into the cornea, the eyes were examined daily to evaluate the number of days of ocular discharge and blepharospasm. Also, after 108 and 204 h, first grading of corneal opacity was done and then four rabbits of each groups were euthanized for bacterial count. The results showed that the means of days of blepharospasm, ocular discharge, and bacterial counts (log CFU mL
) were significantly different in the treatment groups at 108 and 204 h (
<0.0005, ANOVA). According to Tukey's test, Ciprofloxacin plus Ag-NPs plus Betamethasone group was significantly less than Control +, Ag-NPs, and Ag-NPs plus Betamethasone groups for these variables (
< 0.05). The mean rank of opacity scores was significantly different between treatment groups (
= 0.01, Kruskal-Wallis). Mann-Whitney U-test revealed that Ciprofloxacin plus Ag-NPs plus Betamethasone group had significantly better score than Control +, Ag-NPs, and Ag-NPs plus Betamethasone groups (
< 0.05). It seems Ag-NPs can be an appropriate adjuvant for Ciprofloxacin, but due to the results they can't be an alternative for Ciprofloxacin to treat
keratitis.</description><identifier>ISSN: 1735-0328</identifier><identifier>EISSN: 1726-6890</identifier><identifier>PMID: 31089366</identifier><language>eng</language><publisher>Iran: Shaheed Beheshti University of Medical Sciences</publisher><subject>Original</subject><ispartof>Iranian journal of pharmaceutical research : IJPR, 2019-01, Vol.18 (1), p.320-327</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487424/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487424/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31089366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zavarshani, Mohammad</creatorcontrib><creatorcontrib>Ahmadi, Malahat</creatorcontrib><creatorcontrib>Dastmalchi Saei, Habib</creatorcontrib><creatorcontrib>Tehrani, Ali Asghar</creatorcontrib><creatorcontrib>Dalir Naghadeh, Bahram</creatorcontrib><title>Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study</title><title>Iranian journal of pharmaceutical research : IJPR</title><addtitle>Iran J Pharm Res</addtitle><description>is one of the most common causes of keratitis. The current study was done to evaluate the therapeutic effects of antibacterial combinations with Silver nanoparticles (Ag-NPs) and Ciprofloxacin in experimental
keratitis. Sixty four New Zealand rabbits were prepared. All rabbits were randomly categorized into eight groups (each group containing eight rabbits): Control +, Control -, Ciprofloxacin, Ag-NPs, Ciprofloxacin plus Betamethasone, Ag-NPs plus Betamethasone, Ciprofloxacin plus Ag-NPs, and Ciprofloxacin plus Ag-NPs plus Betamethasone. Twelve hours after bacterial inoculation into the cornea, the eyes were examined daily to evaluate the number of days of ocular discharge and blepharospasm. Also, after 108 and 204 h, first grading of corneal opacity was done and then four rabbits of each groups were euthanized for bacterial count. The results showed that the means of days of blepharospasm, ocular discharge, and bacterial counts (log CFU mL
) were significantly different in the treatment groups at 108 and 204 h (
<0.0005, ANOVA). According to Tukey's test, Ciprofloxacin plus Ag-NPs plus Betamethasone group was significantly less than Control +, Ag-NPs, and Ag-NPs plus Betamethasone groups for these variables (
< 0.05). The mean rank of opacity scores was significantly different between treatment groups (
= 0.01, Kruskal-Wallis). Mann-Whitney U-test revealed that Ciprofloxacin plus Ag-NPs plus Betamethasone group had significantly better score than Control +, Ag-NPs, and Ag-NPs plus Betamethasone groups (
< 0.05). It seems Ag-NPs can be an appropriate adjuvant for Ciprofloxacin, but due to the results they can't be an alternative for Ciprofloxacin to treat
keratitis.</description><subject>Original</subject><issn>1735-0328</issn><issn>1726-6890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkUFr3DAQhU1JaLbb_oWiYw4xyJItyzkEwrJtCksSutuzGVvjrhJbciU5ZP9Qfmdkug3NaQbmve89mA_JIiuZSIWs6Mm88yKlnMmz5JP3D5QWosrpx-SMZ1RWXIhF8rKywwhOe2vIbo8ORpyCbsm667ANntiOrPTobNfbZ2i1uSBb3T-hI7dgbDRGbY-egFGzXTsSeY02EHQEakPCHsnOIYQBTZhp9x4nZQdrwJPHmBd00H5W_oSm0eGSXBuyfh7R6dkBPdmGSR0-J6cd9B6_HOcy-fVtvVvdpJu77z9W15t0zCoR0ioTvGMyV1lR8EqqEgCaglVKdYxSzHPETLYN0qwsWlVKQYWQjFVlWzIuWcOXydVf7jg1A6o2VnDQ12NsA-5QW9D1-4vR-_q3fapFLsuc5RFwfgQ4-2dCH-pB-xb7HgzaydeM8dhEClZG6df_s95C_j2HvwJOdJB6</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Zavarshani, Mohammad</creator><creator>Ahmadi, Malahat</creator><creator>Dastmalchi Saei, Habib</creator><creator>Tehrani, Ali Asghar</creator><creator>Dalir Naghadeh, Bahram</creator><general>Shaheed Beheshti University of Medical Sciences</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study</title><author>Zavarshani, Mohammad ; Ahmadi, Malahat ; Dastmalchi Saei, Habib ; Tehrani, Ali Asghar ; Dalir Naghadeh, Bahram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-9163f284d155398d7aaab529ddf200e44ee18cbe0175cd78606682297c72382b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zavarshani, Mohammad</creatorcontrib><creatorcontrib>Ahmadi, Malahat</creatorcontrib><creatorcontrib>Dastmalchi Saei, Habib</creatorcontrib><creatorcontrib>Tehrani, Ali Asghar</creatorcontrib><creatorcontrib>Dalir Naghadeh, Bahram</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Iranian journal of pharmaceutical research : IJPR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zavarshani, Mohammad</au><au>Ahmadi, Malahat</au><au>Dastmalchi Saei, Habib</au><au>Tehrani, Ali Asghar</au><au>Dalir Naghadeh, Bahram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study</atitle><jtitle>Iranian journal of pharmaceutical research : IJPR</jtitle><addtitle>Iran J Pharm Res</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>18</volume><issue>1</issue><spage>320</spage><epage>327</epage><pages>320-327</pages><issn>1735-0328</issn><eissn>1726-6890</eissn><abstract>is one of the most common causes of keratitis. The current study was done to evaluate the therapeutic effects of antibacterial combinations with Silver nanoparticles (Ag-NPs) and Ciprofloxacin in experimental
keratitis. Sixty four New Zealand rabbits were prepared. All rabbits were randomly categorized into eight groups (each group containing eight rabbits): Control +, Control -, Ciprofloxacin, Ag-NPs, Ciprofloxacin plus Betamethasone, Ag-NPs plus Betamethasone, Ciprofloxacin plus Ag-NPs, and Ciprofloxacin plus Ag-NPs plus Betamethasone. Twelve hours after bacterial inoculation into the cornea, the eyes were examined daily to evaluate the number of days of ocular discharge and blepharospasm. Also, after 108 and 204 h, first grading of corneal opacity was done and then four rabbits of each groups were euthanized for bacterial count. The results showed that the means of days of blepharospasm, ocular discharge, and bacterial counts (log CFU mL
) were significantly different in the treatment groups at 108 and 204 h (
<0.0005, ANOVA). According to Tukey's test, Ciprofloxacin plus Ag-NPs plus Betamethasone group was significantly less than Control +, Ag-NPs, and Ag-NPs plus Betamethasone groups for these variables (
< 0.05). The mean rank of opacity scores was significantly different between treatment groups (
= 0.01, Kruskal-Wallis). Mann-Whitney U-test revealed that Ciprofloxacin plus Ag-NPs plus Betamethasone group had significantly better score than Control +, Ag-NPs, and Ag-NPs plus Betamethasone groups (
< 0.05). It seems Ag-NPs can be an appropriate adjuvant for Ciprofloxacin, but due to the results they can't be an alternative for Ciprofloxacin to treat
keratitis.</abstract><cop>Iran</cop><pub>Shaheed Beheshti University of Medical Sciences</pub><pmid>31089366</pmid><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| title | Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study |
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