NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

[Display omitted] Diabetes increases the risk and worsens the progression of cognitive impairment via the greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are not fully understood. It is now accepted that cardiovascular health is critical for brain health and any...

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Veröffentlicht in:	Pharmacological research 2019-04, Vol.142, p.237-250
Hauptverfasser:	Ward, Rebecca, Li, Weiguo, Abdul, Yasir, Jackson, LaDonya, Dong, Guangkuo, Jamil, Sarah, Filosa, Jessica, Fagan, Susan C., Ergul, Adviye
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - immunology Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - immunology Furans - pharmacology Furans - therapeutic use Heterocyclic Compounds, 4 or More Rings Hippocampus Hippocampus - drug effects Hippocampus - immunology Hippocampus - pathology Indenes Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - immunology Inflammasomes - immunology Male Mice Neurons - drug effects Neurons - pathology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurovascular unit NLR Family, Pyrin Domain-Containing 3 Protein - immunology NLRP3 inflammasome Rats, Wistar Stroke Sulfonamides - pharmacology Sulfonamides - therapeutic use Sulfones Vascular cognitive impairment and dementia (VCID)
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