Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for hepatitis B virus (HBV) entry. However, the susceptibility of NTCP-expressing cells to HBV is diverse depending on the culture condition. Stimulation with epidermal growth factor (EGF) was found to potentiate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-04, Vol.116 (17), p.8487-8492
Hauptverfasser:	Iwamoto, Masashi, Saso, Wakana, Sugiyama, Ryuichi, Ishii, Koji, Ohki, Mio, Nagamori, Shushi, Suzuki, Ryosuke, Aizaki, Hideki, Ryo, Akihide, Yun, Ji-Hye, Park, Sam-Yong, Ohtani, Naoko, Muramatsu, Masamichi, Iwami, Shingo, Tanaka, Yasuhito, Sureau, Camille, Wakita, Takaji, Watashi, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Biological Sciences Cell culture Cell membranes Cell surface Deactivation Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Fluorescence Growth factors Hep G2 Cells Hepatitis Hepatitis B Hepatitis B virus - pathogenicity Hepatitis B virus - physiology Host-Pathogen Interactions - genetics Host-Pathogen Interactions - physiology Humans Immunoprecipitation Inactivation Infections Internalization Life Sciences Microbiology and Parasitology Molecular interactions Mutation Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism Peptides Pharmacology Point mutation Sodium Symporters - genetics Symporters - metabolism Viral infections Virions Virology Virus Internalization Viruses
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