Depletion of S-adenosylmethionine impacts on ribosome biogenesis through hypomodification of a single rRNA methylation

Abstract S-adenosylmethionine (SAM) is an essential metabolite and a methyl group donor in all living organisms. The intracellular SAM concentration is tightly regulated, and depletion causes hypomethylation of substrates, growth defects and pathological consequences. In the emerging field of epitra...

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Veröffentlicht in:	Nucleic acids research 2019-05, Vol.47 (8), p.4226-4239
Hauptverfasser:	Ishiguro, Kensuke, Arai, Taiga, Suzuki, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Regulation, Bacterial Genetic Complementation Test Methylation Methyltransferases - genetics Methyltransferases - metabolism Organelle Biogenesis Ribosomes - genetics Ribosomes - metabolism RNA and RNA-protein complexes RNA, Ribosomal - genetics RNA, Ribosomal - metabolism RNA, Ribosomal, 23S - genetics RNA, Ribosomal, 23S - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism S-Adenosylmethionine - metabolism
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