Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n‐3 Polyunsaturated Fatty Acids
Population‐based data suggest that individuals who consume large dietary amounts of n‐3 polyunsaturated fatty acids (PUFA) have lower odds of peripheral artery disease (PAD); however, clinical studies examining n‐3 PUFA levels in patients with PAD are sparse. The objective of this study is to compar...
Gespeichert in:
| Veröffentlicht in: | Lipids 2019-04, Vol.54 (4), p.211-219 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 219 |
|---|---|
| container_issue | 4 |
| container_start_page | 211 |
| container_title | Lipids |
| container_volume | 54 |
| creator | Ramirez, Joel L. Zahner, Greg J. Spaulding, Kimberly A. Khetani, Sukaynah A. Hills, Nancy K. Gasper, Warren J. Harris, William S. Cohen, Beth E. Grenon, S. Marlene |
| description | Population‐based data suggest that individuals who consume large dietary amounts of n‐3 polyunsaturated fatty acids (PUFA) have lower odds of peripheral artery disease (PAD); however, clinical studies examining n‐3 PUFA levels in patients with PAD are sparse. The objective of this study is to compare erythrocyte membrane fatty acid (FA) content between patients with PAD and controls. We conducted a cross‐sectional study of 179 vascular surgery outpatients (controls, 34; PAD, 145). A blood sample was drawn and the erythrocyte FA content was assayed using capillary gas chromatography. We calculated the ratio of the n‐3 PUFA eicosapentaenoic acid (EPA) to the n‐6 PUFA arachidonic acid (ARA) as well as the omega‐3 index (O3I), a measure of erythrocyte content of the n‐3 PUFA, EPA, and docosahexaenoic acid (DHA), expressed as a percentage of total erythrocyte FA. Compared with controls, patients with PAD smoked more and were more likely to have hypertension and hyperlipidemia (p |
| doi_str_mv | 10.1002/lipd.12140 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6486409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2194154005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4200-e81b9dc9f4a1d1924ecf0f5a8e23a2737cad33215bf896aa3ccba2d3fbc797da3</originalsourceid><addsrcrecordid>eNp9kc1uEzEQxy0EoqFw4QGQjwhpW39tdn1Bipp-RApqDnC2vPaYGG3Wwfa22huPwDPyJLhNW8Glp5E1P_9mRn-E3lNyQglhp73f2xPKqCAv0IzWdVtJTpqXaFaaohKM0CP0JqUf5UmFrF-jI07aljfNfIbSBqLfbyHqHi9ihjjhpU-gE-BVwouUgvE6g8W3Pm-xxktw3ngYzISDw-dxytsYzJQBf4FdF_UAePjz6zfHm9BP45B0HuP9_wud84QXxtv0Fr1yuk_w7qEeo28X51_Prqr19eXqbLGuTNmZVNDSTlojndDUUskEGEdcrVtgXLOGN0ZbzhmtO9fKudbcmE4zy11nGtlYzY_R54N3P3Y7sAaGXM5U--h3Ok4qaK_-7wx-q76HGzUX7VwQWQQfHwQx_BwhZbXzyUDflzPDmBSjUtBaEFIX9NMBNTGkFME9jaFE3aWk7lJS9ykV-MO_iz2hj7EUgB6AW9_D9IxKrVeb5UH6F_0toTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2194154005</pqid></control><display><type>article</type><title>Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n‐3 Polyunsaturated Fatty Acids</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Ramirez, Joel L. ; Zahner, Greg J. ; Spaulding, Kimberly A. ; Khetani, Sukaynah A. ; Hills, Nancy K. ; Gasper, Warren J. ; Harris, William S. ; Cohen, Beth E. ; Grenon, S. Marlene</creator><creatorcontrib>Ramirez, Joel L. ; Zahner, Greg J. ; Spaulding, Kimberly A. ; Khetani, Sukaynah A. ; Hills, Nancy K. ; Gasper, Warren J. ; Harris, William S. ; Cohen, Beth E. ; Grenon, S. Marlene</creatorcontrib><description>Population‐based data suggest that individuals who consume large dietary amounts of n‐3 polyunsaturated fatty acids (PUFA) have lower odds of peripheral artery disease (PAD); however, clinical studies examining n‐3 PUFA levels in patients with PAD are sparse. The objective of this study is to compare erythrocyte membrane fatty acid (FA) content between patients with PAD and controls. We conducted a cross‐sectional study of 179 vascular surgery outpatients (controls, 34; PAD, 145). A blood sample was drawn and the erythrocyte FA content was assayed using capillary gas chromatography. We calculated the ratio of the n‐3 PUFA eicosapentaenoic acid (EPA) to the n‐6 PUFA arachidonic acid (ARA) as well as the omega‐3 index (O3I), a measure of erythrocyte content of the n‐3 PUFA, EPA, and docosahexaenoic acid (DHA), expressed as a percentage of total erythrocyte FA. Compared with controls, patients with PAD smoked more and were more likely to have hypertension and hyperlipidemia (p < 0.05). Patients with PAD had a lower mean O3I (5.0 ± 1.7% vs 6.0 ± 1.6%, p < 0.001) and EPA:ARA ratio (0.04 ± 0.02 vs 0.05 ± 0.05, p < 0.001), but greater mean total saturated fats (39.5 ± 2.5% vs 38.5 ± 2.6%, p = 0.01). After adjusting for several patient characteristics, comorbidities, and medications, an absolute decrease of 1% in the O3I was associated with 39% greater odds of PAD (odds ratio [OR] 1.39, 95% confidence interval [CI] 1.03–1.86, and p = 0.03). PAD was associated with a deficiency of erythrocyte n‐3 PUFA, a lower EPA:ARA ratio, and greater mean total saturated fats. These alterations in FA content may be involved in the pathogenesis or development of poor outcomes in PAD.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1002/lipd.12140</identifier><identifier>PMID: 30883776</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aged ; Arachidonic Acid - metabolism ; Atherosclerosis ; Chromatography, Gas ; Cross-Sectional Studies ; Eicosapentaenoic Acid - metabolism ; Erythrocyte Membrane - metabolism ; Fatty Acids, Omega-3 - metabolism ; Fatty Acids, Omega-6 - metabolism ; Fatty Acids, Unsaturated - metabolism ; Female ; Humans ; Lipid analysis ; Male ; Middle Aged ; n‐3 fatty acids ; Peripheral Arterial Disease - metabolism ; Peripheral Arterial Disease - pathology</subject><ispartof>Lipids, 2019-04, Vol.54 (4), p.211-219</ispartof><rights>2019 AOCS</rights><rights>2019 AOCS.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4200-e81b9dc9f4a1d1924ecf0f5a8e23a2737cad33215bf896aa3ccba2d3fbc797da3</citedby><cites>FETCH-LOGICAL-c4200-e81b9dc9f4a1d1924ecf0f5a8e23a2737cad33215bf896aa3ccba2d3fbc797da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flipd.12140$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flipd.12140$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30883776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramirez, Joel L.</creatorcontrib><creatorcontrib>Zahner, Greg J.</creatorcontrib><creatorcontrib>Spaulding, Kimberly A.</creatorcontrib><creatorcontrib>Khetani, Sukaynah A.</creatorcontrib><creatorcontrib>Hills, Nancy K.</creatorcontrib><creatorcontrib>Gasper, Warren J.</creatorcontrib><creatorcontrib>Harris, William S.</creatorcontrib><creatorcontrib>Cohen, Beth E.</creatorcontrib><creatorcontrib>Grenon, S. Marlene</creatorcontrib><title>Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n‐3 Polyunsaturated Fatty Acids</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Population‐based data suggest that individuals who consume large dietary amounts of n‐3 polyunsaturated fatty acids (PUFA) have lower odds of peripheral artery disease (PAD); however, clinical studies examining n‐3 PUFA levels in patients with PAD are sparse. The objective of this study is to compare erythrocyte membrane fatty acid (FA) content between patients with PAD and controls. We conducted a cross‐sectional study of 179 vascular surgery outpatients (controls, 34; PAD, 145). A blood sample was drawn and the erythrocyte FA content was assayed using capillary gas chromatography. We calculated the ratio of the n‐3 PUFA eicosapentaenoic acid (EPA) to the n‐6 PUFA arachidonic acid (ARA) as well as the omega‐3 index (O3I), a measure of erythrocyte content of the n‐3 PUFA, EPA, and docosahexaenoic acid (DHA), expressed as a percentage of total erythrocyte FA. Compared with controls, patients with PAD smoked more and were more likely to have hypertension and hyperlipidemia (p < 0.05). Patients with PAD had a lower mean O3I (5.0 ± 1.7% vs 6.0 ± 1.6%, p < 0.001) and EPA:ARA ratio (0.04 ± 0.02 vs 0.05 ± 0.05, p < 0.001), but greater mean total saturated fats (39.5 ± 2.5% vs 38.5 ± 2.6%, p = 0.01). After adjusting for several patient characteristics, comorbidities, and medications, an absolute decrease of 1% in the O3I was associated with 39% greater odds of PAD (odds ratio [OR] 1.39, 95% confidence interval [CI] 1.03–1.86, and p = 0.03). PAD was associated with a deficiency of erythrocyte n‐3 PUFA, a lower EPA:ARA ratio, and greater mean total saturated fats. These alterations in FA content may be involved in the pathogenesis or development of poor outcomes in PAD.</description><subject>Aged</subject><subject>Arachidonic Acid - metabolism</subject><subject>Atherosclerosis</subject><subject>Chromatography, Gas</subject><subject>Cross-Sectional Studies</subject><subject>Eicosapentaenoic Acid - metabolism</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Fatty Acids, Omega-6 - metabolism</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lipid analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>n‐3 fatty acids</subject><subject>Peripheral Arterial Disease - metabolism</subject><subject>Peripheral Arterial Disease - pathology</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEQxy0EoqFw4QGQjwhpW39tdn1Bipp-RApqDnC2vPaYGG3Wwfa22huPwDPyJLhNW8Glp5E1P_9mRn-E3lNyQglhp73f2xPKqCAv0IzWdVtJTpqXaFaaohKM0CP0JqUf5UmFrF-jI07aljfNfIbSBqLfbyHqHi9ihjjhpU-gE-BVwouUgvE6g8W3Pm-xxktw3ngYzISDw-dxytsYzJQBf4FdF_UAePjz6zfHm9BP45B0HuP9_wud84QXxtv0Fr1yuk_w7qEeo28X51_Prqr19eXqbLGuTNmZVNDSTlojndDUUskEGEdcrVtgXLOGN0ZbzhmtO9fKudbcmE4zy11nGtlYzY_R54N3P3Y7sAaGXM5U--h3Ok4qaK_-7wx-q76HGzUX7VwQWQQfHwQx_BwhZbXzyUDflzPDmBSjUtBaEFIX9NMBNTGkFME9jaFE3aWk7lJS9ykV-MO_iz2hj7EUgB6AW9_D9IxKrVeb5UH6F_0toTA</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Ramirez, Joel L.</creator><creator>Zahner, Greg J.</creator><creator>Spaulding, Kimberly A.</creator><creator>Khetani, Sukaynah A.</creator><creator>Hills, Nancy K.</creator><creator>Gasper, Warren J.</creator><creator>Harris, William S.</creator><creator>Cohen, Beth E.</creator><creator>Grenon, S. Marlene</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201904</creationdate><title>Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n‐3 Polyunsaturated Fatty Acids</title><author>Ramirez, Joel L. ; Zahner, Greg J. ; Spaulding, Kimberly A. ; Khetani, Sukaynah A. ; Hills, Nancy K. ; Gasper, Warren J. ; Harris, William S. ; Cohen, Beth E. ; Grenon, S. Marlene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4200-e81b9dc9f4a1d1924ecf0f5a8e23a2737cad33215bf896aa3ccba2d3fbc797da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Arachidonic Acid - metabolism</topic><topic>Atherosclerosis</topic><topic>Chromatography, Gas</topic><topic>Cross-Sectional Studies</topic><topic>Eicosapentaenoic Acid - metabolism</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Fatty Acids, Omega-6 - metabolism</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Lipid analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>n‐3 fatty acids</topic><topic>Peripheral Arterial Disease - metabolism</topic><topic>Peripheral Arterial Disease - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramirez, Joel L.</creatorcontrib><creatorcontrib>Zahner, Greg J.</creatorcontrib><creatorcontrib>Spaulding, Kimberly A.</creatorcontrib><creatorcontrib>Khetani, Sukaynah A.</creatorcontrib><creatorcontrib>Hills, Nancy K.</creatorcontrib><creatorcontrib>Gasper, Warren J.</creatorcontrib><creatorcontrib>Harris, William S.</creatorcontrib><creatorcontrib>Cohen, Beth E.</creatorcontrib><creatorcontrib>Grenon, S. Marlene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramirez, Joel L.</au><au>Zahner, Greg J.</au><au>Spaulding, Kimberly A.</au><au>Khetani, Sukaynah A.</au><au>Hills, Nancy K.</au><au>Gasper, Warren J.</au><au>Harris, William S.</au><au>Cohen, Beth E.</au><au>Grenon, S. Marlene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n‐3 Polyunsaturated Fatty Acids</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2019-04</date><risdate>2019</risdate><volume>54</volume><issue>4</issue><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Population‐based data suggest that individuals who consume large dietary amounts of n‐3 polyunsaturated fatty acids (PUFA) have lower odds of peripheral artery disease (PAD); however, clinical studies examining n‐3 PUFA levels in patients with PAD are sparse. The objective of this study is to compare erythrocyte membrane fatty acid (FA) content between patients with PAD and controls. We conducted a cross‐sectional study of 179 vascular surgery outpatients (controls, 34; PAD, 145). A blood sample was drawn and the erythrocyte FA content was assayed using capillary gas chromatography. We calculated the ratio of the n‐3 PUFA eicosapentaenoic acid (EPA) to the n‐6 PUFA arachidonic acid (ARA) as well as the omega‐3 index (O3I), a measure of erythrocyte content of the n‐3 PUFA, EPA, and docosahexaenoic acid (DHA), expressed as a percentage of total erythrocyte FA. Compared with controls, patients with PAD smoked more and were more likely to have hypertension and hyperlipidemia (p < 0.05). Patients with PAD had a lower mean O3I (5.0 ± 1.7% vs 6.0 ± 1.6%, p < 0.001) and EPA:ARA ratio (0.04 ± 0.02 vs 0.05 ± 0.05, p < 0.001), but greater mean total saturated fats (39.5 ± 2.5% vs 38.5 ± 2.6%, p = 0.01). After adjusting for several patient characteristics, comorbidities, and medications, an absolute decrease of 1% in the O3I was associated with 39% greater odds of PAD (odds ratio [OR] 1.39, 95% confidence interval [CI] 1.03–1.86, and p = 0.03). PAD was associated with a deficiency of erythrocyte n‐3 PUFA, a lower EPA:ARA ratio, and greater mean total saturated fats. These alterations in FA content may be involved in the pathogenesis or development of poor outcomes in PAD.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30883776</pmid><doi>10.1002/lipd.12140</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-4201 |
| ispartof | Lipids, 2019-04, Vol.54 (4), p.211-219 |
| issn | 0024-4201 1558-9307 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6486409 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Arachidonic Acid - metabolism Atherosclerosis Chromatography, Gas Cross-Sectional Studies Eicosapentaenoic Acid - metabolism Erythrocyte Membrane - metabolism Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-6 - metabolism Fatty Acids, Unsaturated - metabolism Female Humans Lipid analysis Male Middle Aged n‐3 fatty acids Peripheral Arterial Disease - metabolism Peripheral Arterial Disease - pathology |
| title | Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n‐3 Polyunsaturated Fatty Acids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T04%3A30%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peripheral%20Artery%20Disease%20Is%20Associated%20with%20a%20Deficiency%20of%20Erythrocyte%20Membrane%20n%E2%80%903%20Polyunsaturated%20Fatty%20Acids&rft.jtitle=Lipids&rft.au=Ramirez,%20Joel%20L.&rft.date=2019-04&rft.volume=54&rft.issue=4&rft.spage=211&rft.epage=219&rft.pages=211-219&rft.issn=0024-4201&rft.eissn=1558-9307&rft_id=info:doi/10.1002/lipd.12140&rft_dat=%3Cproquest_pubme%3E2194154005%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2194154005&rft_id=info:pmid/30883776&rfr_iscdi=true |