TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance

Transforming growth factor-β (TGF-β) is major inducer of epithelial-to-mesenchymal transition (EMT), which associates with cancer cell metastasis and resistance to chemotherapy and targeted drugs, through both transcriptional and non-transcriptional mechanisms. We previously reported that, in cancer...

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Veröffentlicht in:	Oncogene 2019-04, Vol.38 (17), p.3185-3200
Hauptverfasser:	Tripathi, Veenu, Shin, Jee-Hye, Stuelten, Christina H., Zhang, Ying E.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 13/95 14 14/19 38 38/89 38/90 42/44 45/77 631/67/1347 631/80/86/2368 Alternative splicing Alternative Splicing - genetics Animals Apoptosis Apoptosis - genetics Cancer Cell Biology Cell Line, Tumor Cell survival Chemotherapy Cytoskeleton Drug resistance Drug Resistance, Neoplasm - genetics Epithelial-Mesenchymal Transition - genetics Human Genetics Humans Internal Medicine Isoforms Kinases MAP Kinase Kinase Kinases - genetics Medicine Medicine & Public Health Mesenchyme Metastases Mice NF-κB protein Oncology Phosphorylation - genetics Protein Isoforms - genetics Proteins Repressor Proteins - genetics Ribonucleic acid RNA RNA-binding protein Signal Transduction - genetics Smad3 protein Smad3 Protein - genetics TAK1 protein Transcription Transcription, Genetic - genetics Transforming growth factor Transforming Growth Factor beta - genetics Transforming growth factor-b
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