Can patient-reported outcomes be used instead of clinician-reported outcomes and photographs as primary endpoints of late normal tissue effects in breast radiotherapy trials? Results from the IMPORT LOW trial

•Few patients reported moderate/marked normal tissue effects (NTE) irrespective of assessment method used.•Patients reported more NTE than clinician-reported outcomes or photographs.•Concordance was poor on an individual patient level.•Treatment comparisons were consistent between assessment methods...

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Veröffentlicht in:	Radiotherapy and oncology 2019-05, Vol.134, p.220-230
Hauptverfasser:	Bhattacharya, Indrani S., Haviland, Joanne S., Hopwood, Penelope, Coles, Charlotte E., Yarnold, John R., Bliss, Judith M., Kirby, Anna M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Breast Breast Neoplasms - diagnosis Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Clinical Trials, Phase III as Topic - methods Combined Modality Therapy - methods Disease Progression Endpoint Determination Female Humans Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - pathology Normal tissue effects Patient Reported Outcome Measures Patient-reported Photography - methods PROMs Radiotherapy Radiotherapy - adverse effects Radiotherapy - methods Radiotherapy, Adjuvant Randomized Controlled Trials as Topic - methods Trials
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