Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management
The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein is localized in the nucleus of many tumor cells and correlates with clinical f...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2019-01, Vol.20 (1), p.23-32 |
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| container_title | Asian Pacific Journal of Cancer Prevention |
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| creator | Lian, Haiwei Su, Min Zhu, Yijie Zhou, Yun Soomro, Shahid Hussain Fu, Hui |
| description | The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase
overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein
is localized in the nucleus of many tumor cells and correlates with clinical features in many cases. Increased expression
of CK2 in mice results in the development of various types of carcinomas (both solids and blood related tumors, such
as (breast carcinoma, lymphoma, etc), which reveals its carcinogenic properties. CK2 plays essential roles in many key
biological processes related to carcinoma, including cell apoptosis, DNA damage responses and cell cycle regulation.
CK2 has become a potential anti-carcinoma target. Various CK2 inhibitors have been developed with anti-neoplastic
properties against a variety of carcinomas. Some CK2 inhibitors have showed good results in in vitro and pre-clinical
models, and have even entered in clinical trials. This article will review effects of CK2 and its inhibitors on common
carcinomas in in vitro and pre-clinical studies. |
| doi_str_mv | 10.31557/APJCP.2019.20.1.23 |
| format | Article |
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overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein
is localized in the nucleus of many tumor cells and correlates with clinical features in many cases. Increased expression
of CK2 in mice results in the development of various types of carcinomas (both solids and blood related tumors, such
as (breast carcinoma, lymphoma, etc), which reveals its carcinogenic properties. CK2 plays essential roles in many key
biological processes related to carcinoma, including cell apoptosis, DNA damage responses and cell cycle regulation.
CK2 has become a potential anti-carcinoma target. Various CK2 inhibitors have been developed with anti-neoplastic
properties against a variety of carcinomas. Some CK2 inhibitors have showed good results in in vitro and pre-clinical
models, and have even entered in clinical trials. This article will review effects of CK2 and its inhibitors on common
carcinomas in in vitro and pre-clinical studies.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2019.20.1.23</identifier><identifier>PMID: 30677865</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Review</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2019-01, Vol.20 (1), p.23-32</ispartof><rights>Creative Commons Attribution License</rights><rights>Copyright: © Asian Pacific Journal of Cancer Prevention 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2873-702c89f1f98ad081e9d398f874710fcca694ccc1b80ecfa9789a11d431c8c62c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485562/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485562/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30677865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lian, Haiwei</creatorcontrib><creatorcontrib>Su, Min</creatorcontrib><creatorcontrib>Zhu, Yijie</creatorcontrib><creatorcontrib>Zhou, Yun</creatorcontrib><creatorcontrib>Soomro, Shahid Hussain</creatorcontrib><creatorcontrib>Fu, Hui</creatorcontrib><title>Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase
overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein
is localized in the nucleus of many tumor cells and correlates with clinical features in many cases. Increased expression
of CK2 in mice results in the development of various types of carcinomas (both solids and blood related tumors, such
as (breast carcinoma, lymphoma, etc), which reveals its carcinogenic properties. CK2 plays essential roles in many key
biological processes related to carcinoma, including cell apoptosis, DNA damage responses and cell cycle regulation.
CK2 has become a potential anti-carcinoma target. Various CK2 inhibitors have been developed with anti-neoplastic
properties against a variety of carcinomas. Some CK2 inhibitors have showed good results in in vitro and pre-clinical
models, and have even entered in clinical trials. This article will review effects of CK2 and its inhibitors on common
carcinomas in in vitro and pre-clinical studies.</description><subject>Review</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVUFtLwzAUDqK4Of0FguQH2JpLm6Qvwijetol9mOBbOEvTLbK2I-0E_71xU5kv3zmc813gQ-iSkpjTNJU342KSFzEjNAsQ05jxIzRkiRSRFOzt-GAfoLOueyckSZVMT9GAEyGlEukQTQrf9tY1eOoa6CzOp-waAy7CsekdrPF8ZT1s7LZ3Bs_BL22PAzsHb1zT1oCfoYGlrQP7HJ1UsO7sxc8codf7u3n-GM1eHp7y8SwyTEkeScKMyipaZQpKoqjNSp6pSslEUlIZAyJLjDF0oYg1FWRSZUBpmXBqlBHM8BG63ftutovaliZEe1jrjXc1-E_dgtP_P41b6WX7oUWi0lSwYMD3Bsa3Xedt9aelRO-q1btq9Xe1ATTVjAfV1WHsn-a3S_4FHTJ2OA</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Lian, Haiwei</creator><creator>Su, Min</creator><creator>Zhu, Yijie</creator><creator>Zhou, Yun</creator><creator>Soomro, Shahid Hussain</creator><creator>Fu, Hui</creator><general>West Asia Organization for Cancer Prevention</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management</title><author>Lian, Haiwei ; Su, Min ; Zhu, Yijie ; Zhou, Yun ; Soomro, Shahid Hussain ; Fu, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2873-702c89f1f98ad081e9d398f874710fcca694ccc1b80ecfa9789a11d431c8c62c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lian, Haiwei</creatorcontrib><creatorcontrib>Su, Min</creatorcontrib><creatorcontrib>Zhu, Yijie</creatorcontrib><creatorcontrib>Zhou, Yun</creatorcontrib><creatorcontrib>Soomro, Shahid Hussain</creatorcontrib><creatorcontrib>Fu, Hui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lian, Haiwei</au><au>Su, Min</au><au>Zhu, Yijie</au><au>Zhou, Yun</au><au>Soomro, Shahid Hussain</au><au>Fu, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>20</volume><issue>1</issue><spage>23</spage><epage>32</epage><pages>23-32</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>The Protein kinase CK2 (formerly known as casein kinase 2) is a highly conserved serine/ threonine kinase
overexpressed in various human carcinomas and its high expression often correlates with poor prognosis. CK2 protein
is localized in the nucleus of many tumor cells and correlates with clinical features in many cases. Increased expression
of CK2 in mice results in the development of various types of carcinomas (both solids and blood related tumors, such
as (breast carcinoma, lymphoma, etc), which reveals its carcinogenic properties. CK2 plays essential roles in many key
biological processes related to carcinoma, including cell apoptosis, DNA damage responses and cell cycle regulation.
CK2 has become a potential anti-carcinoma target. Various CK2 inhibitors have been developed with anti-neoplastic
properties against a variety of carcinomas. Some CK2 inhibitors have showed good results in in vitro and pre-clinical
models, and have even entered in clinical trials. This article will review effects of CK2 and its inhibitors on common
carcinomas in in vitro and pre-clinical studies.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>30677865</pmid><doi>10.31557/APJCP.2019.20.1.23</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals |
| subjects | Review |
| title | Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management |
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