Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

The authors show that p53 helps cancer cells survive serine depletion by coordinating metabolic remodelling; a diet lacking serine slowed tumour growth in mice, with p53-null tumours showing greatest sensitivity to serine starvation. Serine deprivation as anticancer mechanism The tumour suppressor p...

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Veröffentlicht in:	Nature (London) 2013-01, Vol.493 (7433), p.542-546
Hauptverfasser:	Maddocks, Oliver D. K., Berkers, Celia R., Mason, Susan M., Zheng, Liang, Blyth, Karen, Gottlieb, Eyal, Vousden, Karen H.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/2327 Aerobiosis Amino acids Animals Antioxidants - metabolism Cancer Cancer cells Cell Cycle Checkpoints Cell Line, Tumor Cell Proliferation Cell Survival Cells, Cultured Citric Acid Cycle Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Disease Models, Animal Energy Metabolism Female G1 Phase Glutathione - biosynthesis Glycolysis - drug effects HCT116 Cells Health aspects Humanities and Social Sciences Humans Labeling letter Metabolites Mice multidisciplinary Neoplasm Transplantation Neoplasms - metabolism Neoplasms - pathology Nucleotides - metabolism Oxidative Stress Phosphorylation Physiological aspects Promoter Regions, Genetic - genetics Proteins Science Serine Serine - biosynthesis Serine - deficiency Serine - metabolism Serine - pharmacology Starvation Tumor suppressor genes Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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