Chronic brain blood-flow imaging device for a behavioral experiment using mice
A chronic brain blood-flow imaging device was developed for cerebrovascular disease treatment. This device comprises a small complementary metal-oxide semiconductor image sensor and a chronic fiber-optic plate window on a mouse head. A long-term cerebral blood-flow imaging technique was established...
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Veröffentlicht in: | Biomedical optics express 2019-04, Vol.10 (4), p.1557-1566 |
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creator | Haruta, Makito Kurauchi, Yuki Ohsawa, Masahiro Inami, Chihiro Tanaka, Risako Sugie, Kenji Kimura, Ayaka Ohta, Yasumi Noda, Toshihiko Sasagawa, Kiyotaka Tokuda, Takashi Katsuki, Hiroshi Ohta, Jun |
description | A chronic brain blood-flow imaging device was developed for cerebrovascular disease treatment. This device comprises a small complementary metal-oxide semiconductor image sensor and a chronic fiber-optic plate window on a mouse head. A long-term cerebral blood-flow imaging technique was established in a freely moving mouse. Brain surface images were visible for one month using the chronic FOP window. This device obtained brain surface images and blood-flow velocity. The blood-flow changes were measured in behavioral experiments using this device. The chronic brain blood-flow imaging device may contribute to determining the cause of cerebrovascular disease and the development of cerebrovascular disease treatment. |
doi_str_mv | 10.1364/boe.10.001557 |
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title | Chronic brain blood-flow imaging device for a behavioral experiment using mice |
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