Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity

Abstract Arsenic exposure is a worldwide health concern associated with an increased risk of skin, lung, and bladder cancer but arsenic trioxide (AsIII) is also an effective chemotherapeutic agent. The current use of AsIII in chemotherapy is limited to acute promyelocytic leukemia (APL). However, As...

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Veröffentlicht in:	Toxicological sciences 2019-05, Vol.169 (1), p.108-121
Hauptverfasser:	Sobh, Amin, Loguinov, Alex, Yazici, Gulce Naz, Zeidan, Rola S, Tagmount, Abderrahmane, Hejazi, Nima S, Hubbard, Alan E, Zhang, Luoping, Vulpe, Chris D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Arsenic Trioxide - pharmacology Cell Survival - drug effects CRISPR-Cas Systems Dose-Response Relationship, Drug Functional Profiling of Arsenic Trioxide Gene Editing Gene Expression Profiling Gene Expression Regulation, Leukemic HEK293 Cells Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Signal Transduction Sodium Selenite - pharmacology Time Factors Transcriptome
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