Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

Membrane targeting of autophagy‐related complexes is an important step that regulates their activities and prevents their aberrant engagement on non‐autophagic membranes. ATG16L1 is a core autophagy protein implicated at distinct phases of autophagosome biogenesis. In this study, we dissected the re...

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Veröffentlicht in:	The EMBO journal 2019-05, Vol.38 (9), p.n/a
Hauptverfasser:	Dudley, Leo J, Cabodevilla, Ainara G, Makar, Agata N, Sztacho, Martin, Michelberger, Tim, Marsh, Joseph A, Houston, Douglas R, Martens, Sascha, Jiang, Xuejun, Gammoh, Noor
Format:	Artikel
Sprache:	eng
Schlagworte:	Anchoring Animals ATG16L1 Autophagy Autophagy-Related Proteins - metabolism Autophagy-Related Proteins - physiology Binding Biosynthesis Cell Membrane - metabolism Cells, Cultured coiled‐coil domain Coils EMBO07 EMBO20 Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Endosomes - metabolism Evolution Fibroblasts - cytology Fibroblasts - metabolism Lipids Maturation Mice Mice, Knockout Phagocytosis phagophore Phosphate-Binding Proteins - physiology Phosphatidylinositol Phosphates - metabolism Phosphoinositides PI3P Proteins rab GTP-Binding Proteins - physiology Recruitment Residues Ubiquitin-Conjugating Enzymes - physiology
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