Long non‐coding RNA ZEB2‐AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple‐negative breast cancer by epigenetically activating ZEB2

The triple‐negative breast cancer is the most malignant type of breast cancer. Its pathogenesis and prognosis remain poor despite the significant advances in breast cancer diagnosis and therapy. Meanwhile, long noncoding RNAs (LncRNAs) play a pivotal role in the progression of malignant tumors. In t...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-05, Vol.23 (5), p.3271-3279
Hauptverfasser:	Zhang, Guoxin, Li, Hongli, Sun, Ruimei, Li, Peirui, Yang, Zhiyi, Liu, Yuanyuan, Wang, Zhaoyan, Yang, Yuling, Yin, Chonggao
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Breast cancer Carcinogenesis - genetics Carcinogenesis - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics cytoskeleton rearrangement Down-Regulation - genetics Epidermal Growth Factor - pharmacology Epigenesis, Genetic - drug effects epithelial mesenchymal transition (EMT) Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Glycogen Synthase Kinase 3 beta - metabolism Humans LncRNA‐ZEB2‐AS1 Mice, SCID Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Original Phosphatidylinositol 3-Kinases - metabolism Polymerization Proto-Oncogene Proteins c-akt - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction - drug effects Signal Transduction - genetics Survival Analysis Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology triple‐negative breast cancer Up-Regulation - drug effects Up-Regulation - genetics Zinc Finger E-box Binding Homeobox 2 - genetics Zinc Finger E-box Binding Homeobox 2 - metabolism
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