Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling

We have identified effects of elevated maternal cortisol (induced by maternal infusion 1 mg·kg ·day ) on fetal cardiac maturation and function using an ovine model. Whereas short-term exposure (115-130-day gestation) increased myocyte proliferation and Purkinje fiber apoptosis, infusions until birth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2019-04, Vol.316 (4), p.R323-R337
Hauptverfasser:	Antolic, Andrew, Li, Mengchen, Richards, Elaine M, Curtis, Celia W, Wood, Charles E, Keller-Wood, Maureen
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Animals, Newborn Apoptosis Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - epidemiology Birth Bone morphogenetic proteins Bradycardia Calcium Calcium metabolism Calcium signalling Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Childbirth & labor Collagen Cortisol Cytoskeleton Female Fetal Heart - drug effects Fetal Heart - physiology Fetuses Gene expression Genes Gestation Heart Heart - drug effects Heart - embryology Heart - growth & development Heart Septum - embryology Heart Septum - growth & development Heart Ventricles - embryology Heart Ventricles - growth & development Hormones Hydrocortisone - metabolism Hydrocortisone - pharmacology Male Mathematical models Maturation Metabolism Modelling Models, Genetic Muscle Cells - drug effects Myocardium Pregnancy Purkinje Fibers - physiology Septum Sheep, Domestic Smad protein Statistical models Transcriptome Ventricle
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!