Adenine acts in the kidney as a signaling factor and causes salt- and water-losing nephropathy: early mechanism of adenine-induced renal injury

Chronic adenine feeding is extensively used to develop animal models of chronic renal failure with metabolic features resembling those observed in humans. However, the mechanism by which adenine induces renal failure is poorly understood. In this study, we examined the early effects of adenine on wa...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2019-04, Vol.316 (4), p.F743-F757
Hauptverfasser:	Dos Santos, Ingrid F, Sheriff, Sulaiman, Amlal, Sihame, Ahmed, Rafeeq P H, Thakar, Charuhas V, Amlal, Hassane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adenine - toxicity Animal models Animals Aquaporin 2 Aquaporin 2 - antagonists & inhibitors Arginine Vasopressin - pharmacology Argipressin Body weight Body weight loss Collecting duct Cyclic AMP - metabolism Diabetes insipidus Diabetes mellitus Diet Dose-Response Relationship, Drug Eating Feeding Food intake Hematocrit Hemoglobin Kidney - drug effects Kidney - pathology Kidney diseases Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Male Metabolism Nephropathy Osmolar Concentration Polydipsia Polyuria Rats Rats, Sprague-Dawley Renal failure Renal tubules Rodents Signal Transduction - drug effects Sodium Sodium chloride Sodium Chloride - pharmacology Solute Carrier Family 12, Member 1 - antagonists & inhibitors Urea Urine Vasopressin Water - metabolism Water-Electrolyte Balance - drug effects
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